Age, Renal Dysfunction, Cardiovascular Disease, and Antihyperglycemic Treatment in Type 2 Diabetes Mellitus: Findings from the Renal Insufficiency and Cardiovascular Events Italian Multicenter Study
Age, Renal Dysfunction, Cardiovascular Disease, and Antihyperglycemic Treatment in Type 2 Diabetes Mellitus: Findings from the Renal Insufficiency and Cardiovascular Events Italian Multicenter Study
复制标题
DOI：
10.1111/jgs.12381
复制
发表时间：
2013-08-01
影响因子：
6.3
通讯作者：
Pugliese, Giuseppe
中科院分区：
文献类型：
--
作者：
Solini, Anna;Penno, Giuseppe;Pugliese, Giuseppe
目的：评估2型糖尿病(T2 DM)患者的降糖治疗在年龄和肾功能方面的分布及其与心血管疾病的关系。设计：横断面分析。集合：2007年和2008年19个以医院为基础的糖尿病诊所。对照：15,733例T2 DM患者，来自意大利多中心肾功能不全和心血管事件研究。使用慢性肾脏疾病流行病学协作方程计算估计的肾小球滤过率(EGFR)。用免疫比浊法或免疫比浊法测定尿蛋白。主要急性心血管事件的患病率根据年龄四分位数、治疗方法和EGFR类别计算(1=90；2=60-89；3=30-59；和4=
OBJECTIVES: To assess the distribution of antihyperglycemic treatments according to age and renal function and its relationship with cardiovascular disease in type 2 diabetes mellitus (T2DM).DESIGN: Cross-sectional analysis.SETTING: Nineteen hospital-based diabetes mellitus clinics in 2007 and 2008.PARTICIPANTS: Fifteen thousand seven hundred thirty-three individuals with T2DM from the Renal Insufficiency and Cardiovascular Events (RIACE) Italian Multicenter Study.MEASUREMENTS: Current antihyperglycemic treatments were recorded. Estimated glomerular filtration rate (eGFR) was calculated using the Chronic Kidney Disease Epidemiology Collaboration equation. Albuminuria was measured using immunonephelometry or immunoturbidimetry. Prevalence of major acute cardiovascular events was calculated according to age quartiles, treatments, and categories of eGFR (1 = >= 90; 2 = 60-89; 3 = 30-59; and 4 =