Essential and Detrimental - an Update on Intracellular Iron Trafficking and Homeostasis.
Essential and Detrimental - an Update on Intracellular Iron Trafficking and Homeostasis.
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DOI：
10.1093/pcp/pcz091
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发表时间：
2019-07
影响因子：
4.9
通讯作者：
G. Vigani;Á. Solti;S. Thomine;K. Philippar
中科院分区：
文献类型：
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作者：
G. Vigani;Á. Solti;S. Thomine;K. Philippar
叶绿体、线粒体和液泡代表了植物细胞的特征性细胞器，在细胞代谢中具有主要功能。叶绿体是光合作用的场所，因此是植物光自养生长的基础和必需的。线粒体在呼吸过程中产生能量，而空泡则充当内部废物和储存室。此外，叶绿体和线粒体是初级和次级代谢的各种化合物的生物合成的场所。为了光合作用和能量产生，叶绿体和线粒体的内膜配备有电子传递链。为了进行适当的电子转移和几种生物合成功能，两种细胞器都含有过渡金属，其中铁是迄今为止最丰富的。虽然铁因此是植物生长和发育所必需的，但当过量和/或以其游离离子形式存在时，它变得有毒。后者的有害影响是由氧化应激的产生引起的。因此，在植物生长发育过程中，铁的运输和体内平衡必须受到严格控制。除了相应的运输和稳态蛋白，液泡在某些发育阶段作为细胞内铁的储存和释放室发挥重要作用。在这篇综述中，我们将总结目前的知识铁的运输和稳态的叶绿体，线粒体和液泡。此外，我们的目标是整合细胞内铁稳态对细胞和发育过程的生理影响。
Chloroplasts, mitochondria, and vacuoles represent characteristic organelles of the plant cell, with a predominant function in cellular metabolism. Chloroplasts are the site of photosynthesis and therefore basic and essential for photoautotrophic growth of plants. Mitochondria produce energy during respiration and vacuoles act as internal waste and storage compartments. Moreover, chloroplasts and mitochondria are sites for the biosynthesis of various compounds of primary and secondary metabolism. For photosynthesis and energy generation, the internal membranes of chloroplasts and mitochondria are equipped with electron transport chains. To perform proper electron transfer and several biosynthetic functions, both organelles contain transition metals and here iron is by far the most abundant. Although iron is thus essential for plant growth and development, it becomes toxic when present in excess and/or in its free, ionic form. The harmful effect of the latter is caused by the generation of oxidative stress. As a consequence, iron transport and homeostasis have to be tightly controlled during plant growth and development. In addition to the corresponding transport and homeostasis proteins, the vacuole plays an important role as an intracellular iron storage and release compartment at certain developmental stages. In this review, we will summarize current knowledge on iron transport and homeostasis in chloroplasts, mitochondria, and vacuoles. In addition, we aim to integrate the physiological impact of intracellular iron homeostasis on cellular and developmental processes.