Examining diabetic nephropathy through the lens of mouse genetics.
Examining diabetic nephropathy through the lens of mouse genetics.
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DOI：
10.1007/s11892-007-0078-3
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发表时间：
2007-12-01
影响因子：
4.2
通讯作者：
Harris, Raymond C
中科院分区：
文献类型：
--
作者：
Breyer, Matthew D;Tchekneva, Elena;Harris, Raymond C
虽然糖尿病肾病只发生在少数糖尿病患者中，但它是美国终末期肾病的主要原因。高血压和高血压是诱发糖尿病肾病患者的重要因素，但越来越多的证据表明，关键的遗传因素诱发糖尿病肾病患者的一个子集。在人群中确定赋予肾病风险的基因一直是具有挑战性的。比较基因组学使用强大的遗传试剂，可在实验室小鼠应提供一个互补的方法来确定基因，可能易患糖尿病肾病的小鼠和人类。本文综述了新的研究，以确定糖尿病肾病的遗传危险因素和独特的方法，可用于阐明这种疾病的遗传发病机制的小鼠。
Although diabetic nephropathy occurs in only a minority of patients with diabetes, it is the major cause of end-stage renal disease in the United States. Hyperglycemia and hypertension are important factors predisposing patients to diabetic nephropathy, but accumulating evidence points to critical genetic factors predisposing only a subset of patients with diabetes to nephropathy. It has been challenging to define the genes conferring risk for nephropathy in human populations. Comparative genomics using the robust genetic reagents available in laboratory mice should provide a complementary approach to defining genes that may predispose to diabetic nephropathy in mice and humans. This article reviews new studies to identify genetic risk factors for diabetic nephropathy and the unique approaches that may be used to elucidate the genetic pathogenesis of this disorder in mice.