Wound edge biopsy sites in chronic wounds heal rapidly and do not result in delayed overall healing of the wounds.
Wound edge biopsy sites in chronic wounds heal rapidly and do not result in delayed overall healing of the wounds.
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DOI：
10.1111/j.1524-475x.2009.00559.x
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发表时间：
2010-01
期刊：
影响因子：
--
通讯作者：
Falanga V
中科院分区：
文献类型：
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作者：
Panuncialman J;Hammerman S;Carson P;Falanga V
伤口活检是慢性伤口管理中的重要诊断组成部分。首先，伤口中恶性肿瘤或感染的可能性通常需要对伤口边缘及其床进行采样。其次，一些实践指南建议对2-6周后对治疗没有反应的伤口进行活检。然而，人们一直担心活检可能会使伤口恶化并延迟整体愈合。在本报告中，我们研究了在进行活检之前和之后，伤口活检对整体慢性伤口愈合率（每周伤口边缘向中心推进）的安全性和影响。在一组14例下肢慢性伤口患者中，我们发现活检后慢性伤口愈合率（0.99±1.18 mm/周;平均值±标准差）并未降低，实际上高于活检前慢性伤口愈合率（0.49±0.85 mm/周;平均值±标准差，p < 0.05）。此外，我们记录了14名受试者中的11名在6周内活检部位愈合至原始伤口边缘。因此，我们得出结论，慢性伤口活检后不会恶化，伤口活检是一种安全的程序，不会延迟慢性伤口的整体愈合。
Wound biopsies are an essential diagnostic component in the management of chronic wounds. First, the possibility of malignancy or infection in the wound often requires sampling of the wound edge and its bed. Secondly, several practice guidelines recommend biopsying wounds that have not responded to treatment after 2–6 weeks. However, there has always been a concern that the biopsy may worsen the wound and delay overall healing. In this report, we investigated the safety and effects of wound biopsies on overall chronic wound healing rates (advance of the wound edge per week toward the center) before and after the biopsy was performed. In a cohort of 14 consecutive patients with chronic wounds of the lower extremity, we found that postbiopsy chronic wound healing rates (0.99±1.18 mm/week; mean±SD) were not decreased and were actually higher than prebiopsy chronic wound healing rates (0.49±0.85 mm/week; mean±SD, p < 0.05). In addition, we documented that healing of the biopsy sites up to the original wound edge occurred within 6 weeks in 11 of the 14 subjects. Therefore, we conclude that chronic wounds do not worsen after being biopsied and that wound biopsies are a safe procedure that does not delay overall healing of the chronic wound.