mTOR signaling in disease
mTOR signaling in disease
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DOI：
10.1016/j.ceb.2011.09.003
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发表时间：
2011-12-01
影响因子：
7.5
通讯作者：
Hall, Michael N.
中科院分区：
文献类型：
--
作者：
Dazert, Eva;Hall, Michael N.
雷帕霉素 (TOR) 的靶标是一种高度保守的丝氨酸/苏氨酸激酶，是细胞生长、代谢和衰老的中央控制器。哺乳动物 TOR (mTOR) 会因营养物质、生长因子和细胞能量而被激活。 mTOR 信号传导失调与重大疾病有关。在这里，我们回顾了 mTOR 在癌症、代谢紊乱、神经系统疾病和炎症中的作用的最新发现。
The target of rapamycin (TOR) is a highly conserved serine/threonine kinase and a central controller of cell growth, metabolism and aging. Mammalian TOR (mTOR) is activated in response to nutrients, growth factors and cellular energy. Dysregulated mTOR signaling has been implicated in major disease. Here we review recent findings on the role of mTOR in cancer, metabolic disorders, neurological diseases, and inflammation.