Disrupted intrinsic functional connectivity in the vegetative state
Disrupted intrinsic functional connectivity in the vegetative state
复制标题
DOI：
10.1136/jnnp.2007.142349
复制
发表时间：
2009-04-01
影响因子：
11
通讯作者：
Canavero, S.
中科院分区：
文献类型：
--
作者：
Cauda, F.;Micon, B. M.;Canavero, S.
这是有争议的自发血氧水平依赖性波动，在休息的大脑中观察到的，反过来反映有意识地指导的心理活动，或者，构成一个内在的属性的功能性脑组织持续存在的意识。该报告首次在三名患者中显示，持续性植物状态（PVS）以功能失调的默认模式网络为标志，几个大脑区域的连接性降低，包括背外侧前额叶皮层和前扣带皮层，特别是在右半球。这一发现支持了这样一种观点，即静息状态与自我意识有关，而右半球的默认状态可能在意识过程中起着重要作用。据推测，默认状态可能作为一个代理标记的PVS意识的内容，因此，可以取代一个更复杂的激活范式。
It is debatable as to whether the spontaneous blood-oxygen-level dependent fluctuations that are observed in the resting brain in turn reflect consciously directed mental activity or, alternatively, constitute an intrinsic property of functional brain organisation persisting in the absence of consciousness. This report shows for the first time, in three patients, that the persistent vegetative state (PVS) is marked by a dysfunctional default mode network, with decreased connectivity in several brain regions, including the dorsolateral prefrontal cortex and anterior cingulated cortex, especially in the right hemisphere. This finding supports the view that the resting state is involved in self-consciousness, and that the right-hemisphere default state may play a major role in conscious processes. It is speculated that the default state may act as a surrogate marker of PVS with awareness contents and, therefore, could replace a more complex activation paradigm.