An fMRI study comparing brain activation between word generation and electrical stimulation of language-implicated acupoints
An fMRI study comparing brain activation between word generation and electrical stimulation of language-implicated acupoints
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DOI：
10.1002/hbm.10098
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发表时间：
2003-03-01
影响因子：
4.8
通讯作者：
Yang, ES
中科院分区：
文献类型：
--
作者：
Li, G;Liu, HL;Yang, ES
我们比较了17名健康、讲普通话的中国男性志愿者（年龄19-26岁）在产生单词过程中的功能磁共振成像（MRI）与电刺激两个语言相关穴位过程中的大脑激活。所有的科目都强烈右利手根据惯用手清单。使用标准功能MRI程序和单词生成范例，在左右额下回（BA 44，45）以及左侧上级颞回（BA 22，42）中观察到显著激活。左半球激活更强，体积更大。电刺激两个语言相关穴位之一，SJ 8（11名受试者）和Du 15（6名受试者），在同一队列中没有单词生成范例，分别在右侧额下回（BA 44，46）和左侧和右侧上级颞回（BA 22，42）产生显著激活。然而，左侧额下回未见激活。此外，电刺激邻近的非穴位没有产生任何显着的大脑激活。虽然我们的研究结果支持穴位脑激活的概念，但针刺SJ 8或Du 15并没有激活左下额叶皮层的典型语言区。Hum.脑图谱18：233-238，2003年。(C)2003 Wiley-Liss，Inc.
We compared the brain activation on functional magnetic resonance imaging (MRI) during word generation with the activation during electrical stimulation of two language-implicated acupoints in 17 healthy, Mandarin-speaking, Chinese male volunteers (age 19-26 years). All subjects were strongly right handed according to a handedness inventory. Using a standard functional MRI procedure and a word-generation paradigm, significant activation was seen in the left and right inferior frontal gyri (BA 44,45) as well as the left superior temporal gyrus (BA 22,42). Stronger activationwith a larger volume was seen in the left hemisphere. Electrical stimulation of either one of the two language-implicated acupoints, SJ 8 (11 subjects) and Du 15 (6 subjects), without the word-generation paradigm in the same cohort, produced significant activation in the right inferior frontal gyrus (BA 44, 46) and in the left and right superior temporal gyri (BA 22, 42), respectively. Nevertheless, no activation was seen in the left inferior frontal gyrus. In addition, electrical stimulation of the adjacent non-acupoints did not produce any significant brain activation. Although our results support the notion of acupoint-brain activation, applying acupuncture at SJ 8 or Du 15 does not activate the typical language areas in the left inferior frontal cortex. Hum. Brain Mapping 18:233-238, 2003. (C) 2003 Wiley-Liss, Inc.