Neural plasticity and treatment-induced recovery of sentence processing in agrammatism.
Neural plasticity and treatment-induced recovery of sentence processing in agrammatism.
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DOI：
10.1016/j.neuropsychologia.2010.06.036
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发表时间：
2010-09
期刊：
影响因子：
2.6
通讯作者：
Parrish TB
中科院分区：
文献类型：
--
作者：
Thompson CK;den Ouden DB;Bonakdarpour B;Garibaldi K;Parrish TB
本研究探讨了与治疗诱导的改善复杂句子生产（和理解）的神经激活模式与中风引起的失语症，考虑到可能的变化，血流往往与中风，包括延迟时间峰值的血流动力学反应功能（HRF）和低灌注组织。失语症参与者进行了听觉验证功能磁共振成像任务，处理对象裂缝，主体裂缝，和简单的主动句，之前和之后的过程中的治疗基础形式（TUF），一种基于语言学的方法治疗失语症句子缺陷，目标是对象关系从句的建设。在长期试验任务中，对患者进行扫描以检查HRF，以解释中风导致的任何局部偏差，并获得灌注图像以评估低灌注组织的区域。进行感兴趣区域（ROI）分析（双侧），模拟12名年龄匹配的健康志愿者执行相同任务时激活的左半球区域中参与者特定的局部HRF，包括额中回和额下回、中央前回、颞中回和上级回以及与复杂句法处理相关的其他区域，包括后外侧裂周和上级顶叶皮质。结果表明，尽管在失语症参与者中，治疗前到治疗后扫描的激活差异存在个体差异，但主效应分析显示，从左侧上级颞叶激活到双侧更后的颞顶区的一般转移。这些反应的达峰时间与血流呈负相关，如用灌注成像测量的。
This study examined patterns of neural activation associated with treatment-induced improvement of complex sentence production (and comprehension) in six individuals with stroke-induced agrammatic aphasia, taking into account possible alterations in blood flow often associated with stroke, including delayed time-to-peak of the hemodynamic response function (HRF) and hypoperfused tissue. Aphasic participants performed an auditory verification fMRI task, processing object cleft, subject cleft, and simple active sentences, prior to and following a course of Treatment of Underlying Forms (TUF), a linguistically based approach for treating aphasic sentence deficits, which targeted object relative clause constructions. The patients also were scanned in a long-trials task to examine HRFs, to account for any local deviations resulting from stroke, and perfusion images were obtained to evaluate regions of hypoperfused tissue. Region-of-interest (ROI) analyses were conducted (bilaterally), modeling participant-specific local HRFs in left hemisphere areas activated by 12 healthy age-matched volunteers performing the same task, including the middle and inferior frontal gyri, precentral gyrus, middle and superior temporal gyri, and insula, and additional regions associated with complex syntactic processing, including the posterior perisylvian and superior parietal cortices. Results showed that, despite individual variation in activation differences from pre- to post-treatment scans in the aphasic participants, main-effects analyses revealed a general shift from left superior temporal activation to more posterior temporoparietal areas, bilaterally. Time-to-peak of these responses correlated negatively with blood flow, as measured with perfusion imaging.
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