POSTNATAL CHANGES IN TRANSDIAPHRAGMATIC PRESSURE IN PIGLETS
POSTNATAL CHANGES IN TRANSDIAPHRAGMATIC PRESSURE IN PIGLETS
复制标题
DOI：
10.1203/00006450-198607000-00016
复制
发表时间：
1986-07-01
影响因子：
3.6
通讯作者：
WOODRUM, DE
中科院分区：
文献类型：
--
作者：
WATCHKO, JF;MAYOCK, DE;WOODRUM, DE
我们在25只出生后4 - 21天（体重1.3-4.0 kg）的麻醉仔猪中检查了膈肌的力量输出，以确定对于给定水平的神经输入，膈肌是否随着成熟而产生更大的力量输出。跨颅压（Pdi）作为我们的肌力输出指标，并在100 Hz的“超大”经静脉膈神经刺激期间测量，以控制神经驱动。平均Pdi为53 ±。17 cm H2O，范围从最小值29 cm H2O到最大值83 cm H2O。Pdi与出生年龄呈显著正相关（r = 0.79，p < 0.001）。此外，Pdi与总体重（r = 0.73，p < 0.001）、Pdi与脑湿重（r = 0.77，p < 0.001）呈正相关。刺激膈神经所需的电压“超最大”与出生后年龄无关（r = 0.02，p = 0.16）。我们的结论是，随着出生后年龄的增加，总体重，和mammatic湿重增加PDI的发展模式存在于仔猪和发生在一个受控的神经驱动水平的背景下。
We examined diaphragmatic force output in 25 anesthetized piglets ranging in postnatal age from 4 to 21 days (weight 1.3-4.0 kg) in order to determine whether the diaphragm produces greater force output with maturation for a given level of neural input. Transdiaphragmatic pressure (Pdi) served as our index of diaphragmatic force output and was measured during "supramaximal" transvenous phrenic nerve stimulation at 100 Hz in order to control neural drive. Mean Pdi was 53 .+-. 17 cm H2O and ranged from a minimum of 29 cm H2O to a maximum of 83 cm H2O. A significant positive correlation between Pdi and postnatal age was observed (r = 0.79, p < 0.001). In addition, positive correlations were noted between Pdi total body weight (r = 0.73, p < 0.001) and Pdi and diaphragmatic wet weight (r = 0.77, p < 0.001). The voltage needed to stimulate the phrenic nerves "supramaximally" did not correlate with postnatal age (r = 0.02, p = 0.16). We conclude that a developmental pattern of increasing Pdi with increasing postnatal age, total body weight, and diaphragmatic wet weight exists in piglets and occurs within the context of a controlled level of neural drive.