ELAM-1 MEDIATES CELL-ADHESION BY RECOGNITION OF A CARBOHYDRATE LIGAND, SIALYL-LEX
ELAM-1 MEDIATES CELL-ADHESION BY RECOGNITION OF A CARBOHYDRATE LIGAND, SIALYL-LEX
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DOI：
10.1126/science.1701274
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发表时间：
1990-11-23
期刊：
影响因子：
56.9
通讯作者：
PAULSON, JC
中科院分区：
文献类型：
--
作者：
PHILLIPS, ML;NUDELMAN, E;PAULSON, JC
中性粒细胞向炎症部位的募集部分是由内皮白细胞粘附分子-1 （ELAM-1）介导的，该分子在血管壁活化的内皮细胞上表达。ELAM-1是lecc - cam或选择素粘附分子家族的一员，该家族含有被认为可识别碳水化合物配体的凝集素基序。在本报告中，ELAM-1的细胞粘附被证明是由碳水化合物配体sialyl-Lewis X （SLex; neuac .alpha. 2,3gal .beta.1,4）介导的(Fuc.alpha。1,3)- glcnac -)，中性粒细胞细胞表面糖蛋白和糖脂碳水化合物基团的末端结构。
Recruitment of neutrophils to sites of inflammation is mediated in part by endothelial leukocyte adhesion molecule-1 (ELAM-1), which is expressed on activated endothelial cells of the blood vessel walls. ELAM-1 is a member of the LEC-CAM or selectin family of adhesion molecules that contain a lectin motif thought to recognize carbohydrate ligands. In this report, cell adhesion by ELAM-1 is shown to be mediated by a carbohydrate ligand, sialyl-Lewis X (SLex; NeuAc.alpha.2,3Gal.beta.1,4 (Fuc.alpha.1,3)-GlcNAc-), a terminal structure found on cell-surface glycoprotein and glycolipid carbohydrate groups of neutrophils.