Cutting edge: Latecomer CD8 T cells are imprinted with a unique differentiation program
Cutting edge: Latecomer CD8 T cells are imprinted with a unique differentiation program
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DOI：
10.4049/jimmunol.177.2.777
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发表时间：
2006-07-15
影响因子：
4.4
通讯作者：
Hedrick, Stephen M.
中科院分区：
文献类型：
--
作者：
D'Souza, Warren N.;Hedrick, Stephen M.
影响T细胞反应的因素，如抗原载量、抗原前体细胞、共刺激分子和细胞因子，在免疫反应过程中会发生巨大变化。我们观察到，抗病毒CD8T细胞不是同时从循环中招募的，而是在3-4天内招募的。因此，当地居民的T细胞和那些后来进入次级淋巴组织的T细胞被准备在171个非常不同的环境中。在反应后期招募的细胞被印上了独特的分化程序，从而降低了它们的增殖幅度，推迟了它们的扩张动力学。此外，我们还发现，“迟来的”CD8T细胞表现出一种独特的表面表型，表明刺激减少，但并不优先招募到存活的记忆细胞池中。这一发现表明，单个T细胞克隆的招募时间决定了随后免疫反应的群体动态。
Factors that influence T cell responses, such as Ag load, APCs, costimulatory molecules, and cytokines, dramatically change during the course of an immune response. We observed that antiviral CD8 T cells were not recruited from circulation simultaneously, but over a period of 3-4 days. Consequently, locally resident T cells and those that entered-secondary lymphoid tissue later were primed 171 very different environments. The cells recruited later in the response were imprinted with a unique differentiation program, such that their magnitude of proliferation was reduced and their kinetics of expansion was delayed. In addition, we found that the "latecomer" CD8 T cells displayed a unique surface phenotype indicative of reduced stimulation but were not preferentially recruited into the surviving pool of memory cells. This finding demonstrates that the timing of recruitment of individual T cell clones determines the population dynamics of the subsequent immune response.