Clearing the Dead: Apoptotic Cell Sensing, Recognition, Engulfment, and Digestion
Clearing the Dead: Apoptotic Cell Sensing, Recognition, Engulfment, and Digestion
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DOI：
10.1101/cshperspect.a008748
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发表时间：
2013-01-01
影响因子：
7.2
通讯作者：
Ravichandran, Kodi S.
中科院分区：
文献类型：
--
作者：
Hochreiter-Hufford, Amelia;Ravichandran, Kodi S.
清除凋亡细胞是细胞程序性死亡的最后阶段。未经清理的身体可能会继发坏死，促进炎症和自身免疫。值得注意的是，即使在细胞周转率高的组织中，由于健康个体有效的清除机制，凋亡细胞也很少见。最近，在理解体内快速清除细胞的步骤方面取得了重大进展。这些包括通过“找到我”信号感知身体，通过“吃我”信号及其同源受体识别身体，调节吞噬所需的细胞骨架重排的信号通路，以及使细胞清除事件保持“免疫沉默”的吞噬细胞的反应。本研究的重点在于我们对这些步骤的理解。
Clearance of apoptotic cells is the final stage of programmed cell death. Uncleared corpses can become secondarily necrotic, promoting inflammation and autoimmunity. Remarkably, even in tissues with high cellular turnover, apoptotic cells are rarely seen because of efficient clearance mechanisms in healthy individuals. Recently, significant progress has been made in understanding the steps involved in prompt cell clearance in vivo. These include the sensing of corpses via "find me" signals, the recognition of corpses via "eat me" signals and their cognate receptors, the signaling pathways that regulate cytoskeletal rearrangement necessary for engulfment, and the responses of the phagocyte that keep cell clearance events "immunologically silent." This study focuses on our understanding of these steps.