g:Profiler-a web server for functional interpretation of gene lists (2016 update).
g:Profiler-a web server for functional interpretation of gene lists (2016 update).
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DOI：
10.1093/nar/gkw199
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发表时间：
2016-07-08
影响因子：
14.9
通讯作者：
Vilo J
中科院分区：
文献类型：
--
作者：
Reimand J;Arak T;Adler P;Kolberg L;Reisberg S;Peterson H;Vilo J
功能富集分析是解释在各种高通量实验中发现的基因列表的关键步骤。g：Profiler研究平坦的和排名的基因列表，并发现统计学上显著的基因本体论术语、途径和其他基因功能相关术语。翻译数百个基因标识符是g：Profiler的另一个核心功能。自2007年首次出版以来，我们的Web服务器已成为基础和翻译研究人员的热门工具。及时性是g：Profiler的主要优势，因为基因组和途径信息与Ensembl数据库在季度更新中同步。g：Profiler支持213个物种，包括哺乳动物和其他脊椎动物、植物、昆虫和真菌。g：Profiler的2016年更新引入了几个新功能。我们增加了进一步的功能数据集来解释基因列表，包括转录因子结合位点预测，孟德尔疾病注释，有关蛋白质表达和复合物的信息以及人类遗传多态性的基因图谱。除了交互式Web界面外，g：Profiler还可以使用我们的R包，Python接口和BioJS组件在计算管道中访问。g：Profiler可以在http://biit.cs.ut.ee/gprofiler/上免费获得。
Functional enrichment analysis is a key step in interpreting gene lists discovered in diverse high-throughput experiments. g:Profiler studies flat and ranked gene lists and finds statistically significant Gene Ontology terms, pathways and other gene function related terms. Translation of hundreds of gene identifiers is another core feature of g:Profiler. Since its first publication in 2007, our web server has become a popular tool of choice among basic and translational researchers. Timeliness is a major advantage of g:Profiler as genome and pathway information is synchronized with the Ensembl database in quarterly updates. g:Profiler supports 213 species including mammals and other vertebrates, plants, insects and fungi. The 2016 update of g:Profiler introduces several novel features. We have added further functional datasets to interpret gene lists, including transcription factor binding site predictions, Mendelian disease annotations, information about protein expression and complexes and gene mappings of human genetic polymorphisms. Besides the interactive web interface, g:Profiler can be accessed in computational pipelines using our R package, Python interface and BioJS component. g:Profiler is freely available at http://biit.cs.ut.ee/gprofiler/.