Design Considerations for CMOS-Integrated Hall-Effect Magnetic Bead Detectors for Biosensor Applications.
Design Considerations for CMOS-Integrated Hall-Effect Magnetic Bead Detectors for Biosensor Applications.
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DOI：
10.1109/jmems.2013.2259615
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发表时间：
2013-06-05
期刊：
影响因子：
--
通讯作者：
Boser B
中科院分区：
文献类型：
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作者：
Skucha K;Gambini S;Liu P;Megens M;Kim J;Boser B
描述了一种基于霍尔效应传感器的片上磁珠标签探测器的设计方法。对标记结合过程和限制最小检测面积的其他因素引起的信号误差进行量化和调整，以满足典型的分析准确度标准。设计了一个8192元霍尔传感器阵列，该阵列采用商用0.18μmCMOS工艺，采用单掩模后处理工艺。该阵列可以在30秒内量化2.8μm微珠1%的表面覆盖率，变异系数为7.4%。这种准确性和速度的结合使这项技术成为基于磁珠标记的生物检测的合适检测平台。
We describe a design methodology for on-chip magnetic bead label detectors based on Hall-effect sensors. Signal errors caused by the label-binding process and other factors that limit the minimum detection area are quantified and adjusted to meet typical assay accuracy standards. The methodology is demonstrated by designing an 8192 element Hall sensor array, implemented in a commercial 0.18 μm CMOS process with single-mask postprocessing. The array can quantify a 1% surface coverage of 2.8 μm beads in 30 seconds with a coefficient of variation of 7.4%. This combination of accuracy and speed makes this technology a suitable detection platform for biological assays based on magnetic bead labels.