Surgical management of appendicular skeletal metastases in thyroid carcinoma.
Surgical management of appendicular skeletal metastases in thyroid carcinoma.
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DOI：
10.1155/2012/417086
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发表时间：
2012
影响因子：
1.5
通讯作者：
Lewis VO
中科院分区：
文献类型：
--
作者：
Satcher RL;Lin P;Harun N;Feng L;Moon BS;Lewis VO
背景。骨是甲状腺癌转移的常见部位，但对接受甲状腺癌骨转移手术的患者的预后因素知之甚少。方法。一项对单一机构的回顾性审查确定了 1988 年至 2011 年间因甲状腺癌骨转移而接受附肢骨骼手术的 41 名患者。结果。根据 Kaplan-Meier 分析，骨转移手术后患者总生存概率为 1 年 72%、5 年 29% 和 8 年 20%。肿瘤切除（P = 0.001）或孤立性骨受累的患者在根据年龄和性别进行调整后的死亡风险较低。与其他亚型相比，组织学诊断为滤泡癌的手术部位疾病进展更频繁（P = 0.023）。多变量分析显示肿瘤亚型、化疗和术前放疗对术后生存没有影响。接受放射性碘治疗的患者在甲状腺切除术后有更好的生存率，但在骨转移手术后却没有更好的生存率。结论。对于因甲状腺癌骨转移而接受手术的患者，如果可能的话，切除骨转移具有生存获益。
Background. Bone is a frequent site of metastasis from thyroid carcinoma, but prognostic factors for patients who have surgery for thyroid carcinoma bone metastases are poorly understood. Methods. A retrospective review at a single institution identified 41 patients that underwent surgery in the appendicular skeleton for thyroid carcinoma bone metastasis from 1988 to 2011. Results. Overall patient survival probability by Kaplan-Meier analysis after surgery for bone metastasis was 72% at 1 year, 29% at 5 years, and 20% at 8 years. Patients who had their tumor excised (P = 0.001) or presented with solitary bone involvement had a lower risk of death following surgery adjusting for age and gender. Disease progression at the surgery site occurred more frequently with a histological diagnosis of follicular carcinoma compared with other subtypes (P = 0.023). Multivariate analysis showed that tumor subtype, chemotherapy, and preoperative radiation treatment had no effect on survival after surgery. Patients treated with radioactive iodine had better survival following thyroidectomy, but not following surgery for bone metastases. Conclusions. For patients undergoing surgery for thyroid cancer bone metastasis, resection of the bone metastasis, if possible, has a survival benefit.
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影响因子：
5.8
作者：
Durante, C.;Haddy, N.;Schlumberger, M.
通讯作者：
Schlumberger, M.
影响因子：
6.6
作者：
Foote, Robert L.;Molina, Julian R.;Bible, Keith C.
通讯作者：
Bible, Keith C.
影响因子：
2.6
作者：
PROYE, CAG;DROMER, DHR;SULMAN, C
通讯作者：
SULMAN, C
肿瘤切除后股骨内置假体患者的步态和功能 - 手术后 12 年对 18 名患者进行了评估
DOI：
10.1080/00016470216319
发表时间：
2002-08-01
期刊：
ACTA ORTHOPAEDICA SCANDINAVICA
影响因子：
--
作者：
Rompen, JC;Ham, SJ;van Horn, JR
通讯作者：
van Horn, JR
影响因子：
6.6
作者：
Pittas, AG;Adler, M;Robbins, RJ
通讯作者：
Robbins, RJ