COMBINED IMAGING MODALITIES: PET/CT AND SPECT/CT
COMBINED IMAGING MODALITIES: PET/CT AND SPECT/CT
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DOI：
10.1097/01.hp.0000334064.46217.20
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发表时间：
2008-11-01
期刊：
影响因子：
2.2
通讯作者：
Maurer, Alan H.
中科院分区：
文献类型：
--
作者：
Maurer, Alan H.
新的放射性药物的最新发展现在允许在细胞水平上对生物过程进行分子成像，以改善疾病的诊断和治疗。融合的PET/CT和SPECT/CT成像系统现在提供来自PET或SPECT的代谢和功能信息以及CT的高空间分辨率和解剖信息。因为这两组图像是融合的，所以正常和异常代谢活动的区域可以映射到可识别的解剖结构。这种功能和解剖结构的融合已经迅速证明了其临床价值，特别是在肿瘤学领域。在心脏病学、神经病学和感染成像领域也有越来越多的临床适应症。F-18氟脱氧葡萄糖（FDG）是目前最常用的PET显像剂。虽然FDG摄取是非特异性的，但它已被证明具有重要的应用，特别是对于癌症患者。可以预见，融合解剖和分子成像将继续取得进展，无论是在更先进仪器（集成CT或MRI与PET和SPECT相机技术）的开发方面，还是在对器官和细胞生物学更具体的生理方面进行成像的新放射性药物方面。
The recent development of new radiopharmaceuticals now permits molecular imaging of biologic processes at the cellular level to improve both the diagnosis and treatment of disease. Fused PET/CT and SPECT/CT imaging systems now provide metabolic and functional information from PET or SPECT combined with the high spatial resolution and anatomic information of CT. Because the two sets of images are fused, areas of normal and abnormal metabolic activity can be mapped to recognizable anatomic structures. This fusion of function and anatomy has quickly demonstrated its clinical value, especially in the field of oncology. There are also growing clinical indications in the areas of cardiology, neurology, and imaging of infection. F-18 fluorodeoxyglucose (FDG) is the PET imaging agent currently in most common use. While FDG uptake is nonspecific, it has demonstrated important applications, especially for patients with cancer. Continued progress in fused anatomic and molecular imaging can be anticipated, both in the development of more advanced instrumentation (integrated CT or MRI with PET and SPECT camera technology) and with new radiopharmaceuticals that image more specific physiologic aspects of organ and cell biology.