HYPERTENSION, PERFUSION-PRESSURE, AND PRIMARY OPEN-ANGLE GLAUCOMA - A POPULATION-BASED ASSESSMENT
HYPERTENSION, PERFUSION-PRESSURE, AND PRIMARY OPEN-ANGLE GLAUCOMA - A POPULATION-BASED ASSESSMENT
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DOI：
10.1001/archopht.1995.01100020100038
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发表时间：
1995-02-01
影响因子：
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通讯作者：
JAVITT, JC
中科院分区：
文献类型：
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作者：
TIELSCH, JM;KATZ, J;JAVITT, JC
目的：评估血管因素与原发性开角型青光眼（POAG）的相关性。设计：一项基于人群的黑人和白色居民眼病患病率调查。设置：马里兰州东巴尔的摩社区。参与者：5308名40岁或以上居民的分层整群抽样。主要结果测量：原发性开角型青光眼，定义为基于视野和/或视盘发现的可证实的青光眼性视神经损伤。结果：收缩压、舒张压与POAG呈中度正相关。血压对POAG的影响随年龄而改变，在老年受试者中相关性更强。较低的灌注压（血压眼内压）与POAG的患病率增加密切相关，在最低类别的灌注压.结论：这些结果表明，POAG与改变相关的因素，眼血流和故障的自动调节。
Objective: To evaluate the association of vascular factors with primary open-angle glaucoma (POAG).Design: A population-based prevalence survey of ocular disease among black and white residents.Setting: Communities of east Baltimore, Md.Participants: A stratified cluster sample of 5308 residents 40 years of age or older.Main Outcome Measures: Primary open-angle glaucoma as defined by demonstrable glaucomatous optic nerve damage based on visual fields and/or optic disc findings. Intraocular pressure level was not a criterion for diagnosis.Results: Systolic and diastolic blood pressure showed modest, positive association with POAG. The effect of blood pressure on POAG was modified by age, with a stronger association among older subjects. Lower perfusion pressure (blood pressure-intraocular pressure) was strongly associated with an increased prevalence of POAG, with a sixfold excess for those in the lowest category of perfusion pressure.Conclusion: These results suggest that POAG is associated with an alteration in factors related to ocular blood flow and a breakdown of autoregulation.