Synthesis of 2-aminobenzothiazole via FeCl3-catalyzed tandem reaction of 2-iodoaniline with isothiocyanate in water
Synthesis of 2-aminobenzothiazole via FeCl3-catalyzed tandem reaction of 2-iodoaniline with isothiocyanate in water
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DOI：
10.1039/c0gc00123f
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发表时间：
2010-01-01
期刊：
影响因子：
9.8
通讯作者：
Peng, Yi-Yuan
中科院分区：
文献类型：
--
作者：
Ding, Qiuping;Cao, Banpeng;Peng, Yi-Yuan
研究了FeCl 3催化的2-碘苯胺与异硫氰酸酯在水溶液中的串联反应，为2-氨基苯并噻唑的合成提供了一条环境友好、高效实用的路线。本发明的串联方法在十八烷基三甲基氯化铵作为相转移催化剂的存在下显示出宽的底物范围。此外，反应介质可以回收和再循环而不损失效率。
An FeCl3-catalyzed tandem reaction of 2-iodoaniline with isothiocyanate in water is described, which provides an environmentally benign, efficient, and practical route for the generation of 2-aminobenzothiazole. This present tandem process shows broad substrate scope in the presence of octadecyltrimethylammonium chloride as a phase-transfer catalyst. In addition, the reaction media can be recovered and recycled without loss of efficiency.