Isolation of Bordetella pertussis in blood culture from a patient with multiple myeloma.
Isolation of Bordetella pertussis in blood culture from a patient with multiple myeloma.
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DOI：
10.1016/j.jinf.2005.04.014
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发表时间：
2006-01-01
期刊：
影响因子：
--
通讯作者：
Steinbakk, Martin
中科院分区：
文献类型：
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作者：
Troseid, Marius;Jonassen, Tom Oystein;Steinbakk, Martin
百日咳博德泰拉是一种挑剔的需氧，革兰氏阴性的球芽孢杆菌，引起百日咳的经典疾病。我们报告一位63岁男性多发性骨髓瘤患者，因咳嗽、声音嘶哑和发烧而入院。怀疑为支气管肺炎，经2个疗程的β -内酰胺类抗生素治疗，临床效果良好，但呼吸道症状持续存在。最终，百日咳杆菌在有氧血液培养中生长。延迟用克拉霉素治疗对他的咳嗽几乎没有效果。据我们所知，这是第三例报告的百日咳杆菌血症病例。三名患者均出现免疫功能低下。在血培养中可能生长缓慢，需要将血培养瓶和传代培养到特殊培养基中孵育（至少6天），以分离百日咳双球菌。
Bordetella pertussis is a fastidious aerobic, Gram-negative coccobacillus that causes the classical disease of whooping cough. We present a 63 years old man with multiple myeloma who was admitted to the medical department with cough, hoarseness and fever. Bronchopneumonia was suspected and two courses of beta-lactam antibiotics had beneficial effect on his clinical condition, but his respiratory symptoms persisted. Eventually, B. pertussis grew in an aerobic blood culture. Delayed treatment with clarithromycin had little or no effect on his cough. To our knowledge this is the third reported case of B. pertussis bacteraemia. All three patients have been immunocompromized. Growth in blood culture may be slow, and prolonged incubation (at least 6 days) of the blood culture bottles and subculture to a special culture medium is necessary for isolation of B. pertussis.