Intake of 7,8-dihydroxyflavone from pregnancy to weaning prevents cognitive deficits in adult offspring after maternal immune activation
Intake of 7,8-dihydroxyflavone from pregnancy to weaning prevents cognitive deficits in adult offspring after maternal immune activation
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DOI：
10.1007/s00406-017-0802-1
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发表时间：
2017-08-01
影响因子：
4.7
通讯作者：
Hashimoto, Kenji
中科院分区：
文献类型：
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作者：
Han, Mei;Zhang, Ji-chun;Hashimoto, Kenji
脑源性神经营养因子（BDNF）及其高亲和力受体原肌球蛋白受体激酶B（Trk B）信号通路在脑神经发育中起关键作用。妊娠小鼠暴露于聚肌胞苷酸[poly（I：C）]会导致成年后代的认知缺陷。从怀孕到断奶，在poly（I：C）处理的怀孕小鼠中补充TrkB激动剂7，8-二羟基黄酮可以防止认知缺陷的发生，并减少其成年后代前额叶皮层中的BDNF-TrkB信号传导。这些研究结果表明，在具有超高精神病风险的孕妇中补充TrkB激动剂可能会减少其后代精神病的发展。
Brain-derived neurotrophic factor (BDNF) and its high-affinity receptor, tropomyosin receptor kinase B (TrkB) signaling plays a key role in the brain neurodevelopment. The exposure of pregnant mice to polyinosinic-polycytidylic acid [poly(I:C)] causes cognitive deficits in adult offspring. Supplementation with a TrkB agonist, 7,8-dihydroxyflavone, in poly(I:C)-treated pregnant mice from pregnancy to weaning could prevent the onset of cognitive deficits and reduced BDNF-TrkB signaling in the prefrontal cortex of their adult offspring. These findings suggest that supplementation with a TrkB agonist in pregnant women with an ultra-high risk of psychosis may reduce the development of psychosis in their offspring.