Exposure-response analysis of risk of respiratory disease associated with occupational exposure to chrysotile asbestos
Exposure-response analysis of risk of respiratory disease associated with occupational exposure to chrysotile asbestos
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DOI：
10.1136/oem.54.9.646
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发表时间：
1997-09-01
影响因子：
4.9
通讯作者：
Lemen, R
中科院分区：
文献类型：
--
作者：
Stayner, L;Smith, R;Lemen, R
目的-为了评估替代模型和估计肺癌和石棉肺的死亡风险后，职业暴露于温石棉asbestosis. Methods-数据被用来从最近更新的队列死亡率研究工人在南卡罗来纳州纺织厂。采用Poisson回归评价了替代的风险-响应模型。还拟合了设计用于评价阈值反应证据的模型。肺癌和石棉肺的终生风险估计精算方法，占竞争的死因。结果一个非常显着的风险反应关系，发现肺癌和石棉肺。肺癌的发病率-反应关系在乘法尺度上似乎是线性的，这与先前对肺癌和石棉暴露的分析一致。相比之下，石棉肺的发病率-反应关系似乎是非线性的乘法规模在这项分析中。在肺癌或石棉沉滞症的模型中没有明显的阈值证据，在最近修订的OSHA标准0.1纤维/ml下暴露45年的白色男性的额外终生风险预计约为肺癌的5/1000，石棉肺为2/1000。结论-这项研究证实了以前的调查结果，即强烈暴露-接触温石棉与肺癌和石棉肺死亡率之间的反应关系。从这一分析得出的肺癌风险估计值高于从接触温石棉的其他人群得出的风险估计值。这种差异的可能原因进行了讨论。
Objectives-To evaluate alternative models and estimate risk of mortality from lung cancer and asbestosis after occupational exposure to chrysotile asbestos.Methods-Data were used from a recent update of a cohort mortality study of workers in a South Carolina textile factory. Alternative exposure-response models were evaluated with Poisson regression. A model designed to evaluate evidence of a threshold response was also fitted. Lifetime risks of lung cancer and asbestosis were estimated with an actuarial approach that accounts for competing causes of death.Results-A highly significant exposure-response relation was found for both lung cancer and asbestosis. The exposure-response relation for lung cancer seemed to be linear on a multiplicative scale, which is consistent with previous analyses of lung cancer and exposure to asbestos. In contrast, the exposure-response relation for asbestosis seemed to be nonlinear on a multiplicative scale in this analysis. There was no significant evidence for a threshold in models of either the lung cancer or asbestosis, The excess lifetime risk for white men exposed for 45 years at the recently revised OSHA standard of 0.1 fibre/ml was predicted to be about 5/1000 for lung cancer, and 2/1000 for asbestosis.Conclusions-This study confirms the findings from previous investigations of a strong exposure-response relation between exposure to chrysotile asbestos and mortality from lung cancer, and asbestosis. The risk estimates for lung cancer derived from this analysis are higher than those derived from other populations exposed to chrysotile asbestos. Possible reasons for this discrepancy are discussed.