The 27 Facial Sutures: Timing and Clinical Consequences of Closure.
The 27 Facial Sutures: Timing and Clinical Consequences of Closure.
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DOI：
10.1097/prs.0000000000008816
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发表时间：
2022-03-01
影响因子：
3.6
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中科院分区：
文献类型：
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面部缝合对出生后面部发育有很大贡献，但其在头面部病理中的潜在作用尚未得到充分研究。自20世纪中叶以来，人们对面部缝合的发育和生理的兴趣达到顶峰，因此，面部缝合并没有像颅骨缝合或颅底软骨内关节那样引起临床研究的兴趣。除了加强面部骨骼的复杂结构外，面部缝合还可以吸收机械应力，并通常在青春期保持畅通，因为它们调节面部骨骼的生长和细化形状。然而，出生后这些成骨部位的过早关闭会导致生长载体的破坏和随之而来的畸形。虽然单独缝合的病理会导致孤立的面部畸形，但我们假设，跨多个缝合的全面性病理可能涉及复杂的颅面情况，如综合征颅缝融合。在这项工作中，我们全面回顾了27个关键的面部缝合，包括生理成熟和闭合，对出生后面部发育的贡献，以及过早闭合的临床后果。
Facial sutures contribute significantly to postnatal facial development, but their potential role in craniofacial pathology is understudied. Since interest in their development and physiology peaked in the mid-20th century, facial sutures have not garnered nearly the same clinical research interest as calvarial sutures or cranial base endochondral articulations. In addition to reinforcing the complex structure of the facial skeleton, facial sutures absorb mechanical stress and generally remain patent into adolescence as they mediate growth and refine the shape of facial bones. However, premature closure of these sites of postnatal osteogenesis leads to disrupted growth vectors and consequent dysmorphologies. While pathology in individual sutures results in isolated facial deformities, we posit that generalized pathology across multiple may be involved in complex craniofacial conditions such as syndromic craniosynostosis. In this work, we comprehensively review 27 key facial sutures, including physiologic maturation and closure, contributions to postnatal facial development, and clinical consequences of premature closure.