High Expression of Cathepsin E is Associated with the Severity of Airflow Limitation in Patients with COPD
High Expression of Cathepsin E is Associated with the Severity of Airflow Limitation in Patients with COPD
复制标题
组织蛋白酶 E 的高表达与 COPD 患者气流受限的严重程度相关
DOI：
10.3109/15412555.2015.1057273
复制
发表时间：
2016-03-03
影响因子：
2.2
通讯作者：
Xu, Jin-Fu
中科院分区：
文献类型：
--
作者：
Cao, Wei-Jun;Li, Man-Hui;Xu, Jin-Fu
背景：据报道，组织蛋白酶 E (Cat E) 在抗原加工和肺气肿的发展中发挥着关键作用。本研究的目的是探讨 Cat E 和气流受限在 COPD 发病机制中的作用。方法：纳入 65 名 COPD 患者、20 名无 COPD 的吸烟对照受试者和 15 名不吸烟健康对照受试者。通过 ELISA 测定痰和血清样本中 Cat E 和 EIC（弹性蛋白酶抑制能力）的表达，并根据不同亚组进行比较。结果：COPD 患者的 Cat E 浓度显着高于吸烟对照组和非吸烟对照组（P < 0.01）。 COPD 患者的 CatE 水平与预测的 FEV1% 呈负相关（r = -0.95，P < 0.01）。 COPD患者EIC水平与预测的FEV1%呈负相关（r = 0.926，P < 0.01）。 Cat E 水平也与 EIC 水平呈负相关（r = -0.922，P < 0.01）。结论：Cat E 导致 COPD 进展期间气流受限的严重程度。
Background: It was reported that Cathepsin E (Cat E) plays a critical role in antigen processing and in the development of pulmonary emphysema. The aim of this study was to investigate the role of Cat E and airflow limitation in the pathogenesis of COPD. Methods: Sixty-five patients with COPD, 20 smoking control subjects without COPD and 15 non-smoking healthy control subjects were enrolled. Cat E and EIC (Elastase inhibitory capacity) expressions were measured by ELISA in sputum and serum samples and compared according to different subgroups. Results: Cat E concentrations were significantly higher in patients with COPD than smoking control and non-smoking control subjects (P < 0.01). The levels of CatE were inversely correlated with FEV1% predicted in COPD patients (r = -0.95, P < 0.01). The levels of EIC were inversely positively correlated with FEV1% predicted in COPD patients (r = 0.926, P < 0.01). Levels of Cat E were also inversely correlated with the levels of EIC (r = -0.922, P < 0.01). Conclusions: Cat E contributes to the severity of airflow limitation during progression of COPD.