Influence of physical inactivity on arterial compliance during a glucose challenge.
Influence of physical inactivity on arterial compliance during a glucose challenge.
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DOI：
10.1113/ep086713
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发表时间：
2018-04-01
影响因子：
2.7
通讯作者：
Fadel PJ
中科院分区：
文献类型：
--
作者：
Credeur DP;Reynolds LJ;Holwerda SW;Vranish JR;Young BE;Wang J;Thyfault JP;Fadel PJ
急性高血糖已被证明会增加胰岛素抵抗和其他合并症患者的动脉僵硬指数，然而，在健康的年轻人中存在矛盾的结果。我们研究了口服葡萄糖耐量试验（OGTT）后急性高血糖是否会增加健康运动男性的动脉僵硬度，然后在减少动态体力活动以降低胰岛素敏感性之后。从多普勒超声获得的高分辨率动脉直径示踪允许在心脏周期内从直径示踪获得动脉血压（BP）波形。在24例受试者中，该方法与传统的用压平血压计评估动脉顺应性的方法证明了充分的一致性。在10名男性中，连续记录在静止、60和120分钟OGTT时的股动脉和肱动脉直径，以及在减少活动5天（bbb10万至< 5000步/天）之前和之后的搏动血压（Finometer）。对柔度和刚度进行量化。在活动降低之前，OGTT对动脉顺应性或β -僵硬没有影响。然而，活动减少后，在OGTT期间，股骨顺应性下降（休息= 0.10±0.03至120分钟OGTT= 0.06±0.02 mm2/mmHg， P<0.001），股骨β -僵硬度增加（休息= 8.7±2.7至120分钟OGTT= 15.3±6.5 AU， P<0.001），而肱动脉顺应性（P=0.182）或僵硬度未发生变化（P=0.892）。胰岛素敏感性（松田指数）随活性降低而降低（P=0.002）。总之，在年轻健康男性中，在活动减少5天后，股动脉容易发生急性高血糖，从而导致胰岛素敏感性下降，这突出了日常身体活动水平对血管生理的强烈影响。
Acute hyperglycemia has been shown to augment indices of arterial stiffness in patients with insulin resistance and other co-morbidities, however, conflicting results exist in healthy young individuals. We examined if acute hyperglycemia following an oral glucose tolerance test (OGTT) increases arterial stiffness in healthy active men before, and then after reduced ambulatory physical activity to decrease insulin sensitivity. High-resolution arterial diameter tracings acquired from Doppler-ultrasound allowed the obtainment of an arterial blood pressure (BP) waveform from the diameter tracing within a cardiac cycle. In 24 subjects, this method demonstrated sufficient agreement with the traditional approach for assessing arterial compliance using applanation tonometry. In 10 men, continuous recordings of femoral and brachial artery diameter, and beat-to-beat BP (Finometer) were acquired at rest, 60, and 120 mins of an OGTT before and after 5 days of reduced activity (>10,000 to <5,000 steps/day). Compliance and beta-stiffness were quantified. Prior to reduced activity, OGTT had no effect on arterial compliance or beta-stiffness. However, following reduced activity, femoral compliance was decreased (rest= 0.10±0.03 to 120-min OGTT= 0.06±0.02 mm2/mmHg; P<0.001) and femoral beta-stiffness increased (rest= 8.7±2.7 to 120-min OGTT= 15.3±6.5 AU; P<0.001) during OGTT, while no changes occurred in brachial artery compliance (P=0.182) or stiffness (P=0.892). Insulin sensitivity (Matsuda Index) was decreased following reduced activity (P=0.002). In summary, in young healthy men, the femoral artery becomes susceptible to acute hyperglycemia following 5 days of reduced activity and the resultant decrease in insulin sensitivity, highlighting the strong influence of daily physical activity levels on vascular physiology.