Irritability in boys with autism spectrum disorders: an investigation of physiological reactivity.
Irritability in boys with autism spectrum disorders: an investigation of physiological reactivity.
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DOI：
10.1111/jcpp.12382
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发表时间：
2015-10
期刊：
影响因子：
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通讯作者：
Stringaris A
中科院分区：
文献类型：
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作者：
Mikita N;Hollocks MJ;Papadopoulos AS;Aslani A;Harrison S;Leibenluft E;Simonoff E;Stringaris A
自闭症谱系障碍(ASD)患者的易怒是常见的，也是有害的，但其机制仍未得到充分研究。我们调查了ASD的症状报告和易怒的机制，重点是易怒和生理应激反应之间的关系。47名患有高功能自闭症(HFASD)的未服用药物的男孩和23名年龄在10-16岁之间的典型发育男孩完成了心理社会压力测试。记录整个测试过程中皮质醇、心率和心率变异性的变化。获得了自我报告和父母报告的易怒指标。将HFASD组的易怒症状报告与两组没有ASD的男孩进行比较：高度易怒男孩(严重情绪失调，SMD；n=440)和健康对照组男孩(HC；n=430)。患有HFASD的男孩在易怒方面的得分明显高于HC男孩，他们报告的易怒症状模式与SMD男孩非常相似。父母报告和自我报告对高血压病患者易怒的内部一致性较高。尽管患有HFASD的男孩在压力下表现出皮质醇和心率的显著变化，但在整个测试过程中，那些认为自己高度易怒的男孩的皮质醇水平低于那些易怒程度较低的男孩。被父母评为高度易怒的参与者对压力的皮质醇和心率反应迟钝。易怒对心率的影响，而不是皮质醇，被特质焦虑所解释。应激性可以在HFASD中可靠地测量，并与对应激的不同生物反应有关。
Irritability in people with autism spectrum disorders (ASD) is common and impairing, yet its mechanisms remain understudied. We investigated symptom reporting and mechanisms of irritability in ASD, focusing on the relation between irritability and physiological stress responses. Forty‐seven unmedicated boys with high‐functioning ASD (hfASD) and 23 typically developing boys aged 10–16 years completed a psychosocial stress test. Changes in cortisol, heart rate and heart rate variability throughout the test were recorded. Self‐ and parent‐reported measures of irritability were obtained. Irritability symptom reporting in the hfASD group was compared to two groups of boys without ASD: highly irritable boys (severe mood dysregulation, SMD; n = 40) and healthy‐control boys (HC; n = 30). Boys with hfASD scored significantly higher on irritability than HC boys, and they reported a pattern of irritability symptoms closely resembling that of boys with SMD. The internal consistency of irritability in hfASD was high by parent‐ and self‐report. Although boys with hfASD showed significant stress‐induced changes in cortisol and heart rate, those who rated themselves as highly irritable had lower cortisol levels throughout the test compared to those low on irritability. Participants rated as highly irritable by their parents showed blunted cortisol and heart rate responses to stress. The effects of irritability on heart rate, but not cortisol, were accounted for by trait anxiety. Irritability can be measured reliably in hfASD and is associated with distinct biological responses to stress.