Crystals, inflammation, and osteoarthritis.
Crystals, inflammation, and osteoarthritis.
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DOI：
10.1097/bor.0b013e3283432d1f
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发表时间：
2011-03
影响因子：
5.1
通讯作者：
Rosenthal AK
中科院分区：
文献类型：
--
作者：
Rosenthal AK
焦磷酸钙二水合物（CPPD）和碱性磷酸钙（BCP）晶体是骨关节炎关节液和组织的常见成分。这些晶体形成的原因以及它们如何导致骨关节炎（OA）的关节损伤仍不清楚。随着人们对炎症作为OA关键组成部分的重新关注，含钙晶体在这种常见疾病中的作用值得重新检查。有充分的证据支持炎症在OA中的致病作用，并且先天免疫系统可能参与该炎症过程。最近的工作加强了几乎普遍存在的含钙晶体的组织中的患者与终末期OA。含钙晶体可能通过与先天免疫系统组分的直接相互作用以及通过诱导或放大其他炎症信号而导致OA组织中的炎症。越来越多的证据表明，含钙晶体有助于OA，其炎症特性可能通过先天免疫信号介导有害作用。因此，含钙晶体可能是OA的重要治疗靶点。
Calcium pyrophosphate dihydrate (CPPD) and basic calcium phosphate (BCP) crystals are common components of osteoarthritic joint fluids and tissues. Why these crystals form and how they contribute to joint damage in osteoarthritis (OA) remains unclear. With renewed interest in inflammation as a key component of OA the role of calcium-containing crystals in this common disease warrants re-examination. There is ample evidence supporting a pathogenic role for inflammation in OA, and the innate immune system likely participates in this inflammatory process. Recent work reinforces the almost universal existence of calcium-containing crystals in tissues from patients with end-stage OA. Calcium-containing crystals may contribute to inflammation in OA tissues through their direct interactions with components of the innate immune system, as well as by inducing or amplifying other inflammatory signals. There is increasing evidence that calcium-containing crystals contribute to OA and their inflammatory properties may mediate detrimental effects through innate immunity signals. Calcium-containing crystals may thus represent important therapeutic targets in OA.