TRANSPLACENTAL EFFECT OF ETHINYL ESTRADIOL ON MOUSE VAGINAL EPITHELIUM *
TRANSPLACENTAL EFFECT OF ETHINYL ESTRADIOL ON MOUSE VAGINAL EPITHELIUM *
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乙炔雌二醇对小鼠阴道上皮的经胎盘效应*
DOI：
10.1111/j.1440-169x.1977.00241.x
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发表时间：
1977
期刊：
影响因子：
4.6
通讯作者：
H. Nishimura
中科院分区：
文献类型：
--
作者：
Y. Yasuda;T. Kihara;H. Nishimura
用组织学方法观察了孕期给予雌二醇(EE)对成年小鼠阴道上皮细胞的影响。这些小鼠是JCL/ICR品系小鼠的后代，从妊娠第11天到第17天，在胚胎刚刚出现泌尿生殖窦的阶段，每天口服0.02 mg/kg体重或0.01 mg/kg橄榄油溶解的EE。对照组小鼠是那些只用这种交通工具喂养的小鼠的后代。在10-14周龄时进行尸检。另一组暴露于0.02 mg/kg/d的EE或宫内单独染毒，16周龄处死，32周龄处死。未去势小鼠阴道上皮细胞增生，角化程度较强。上皮明显增厚，呈剂量-反应关系。宫内染毒0.01 mg/kg/d的16只小鼠中，1只间质有囊状或腺样结构，表面上皮由柱状细胞组成的粘液分泌细胞。
The effect of prenatal administration of ethinyl estradiol (EE) on the vaginal epithelium of adult mice was examined histologically. The mice were the offspring of JCL/ICR strain mice given orally 0.02 mg/kg body weight/day or 0.01 mg/kg/day of EE dissolved in olive oil from day 11 to day 17 of gestation at a stage when the urogenital sinus has just appeared in the embryos. The control mice were offspring of those fed with the vehicle alone. Autopsies were performed at 10 to 14 weeks of age. Another group of mice exposed to 0.02 mg/kg/day of EE or vehicle alone in utero, were spayed at 16 weeks of age and killed at 32 weeks of age. In the experimental nonspayed mice, hyperplasia of the vaginal epithelium with intense cornification was seen. The epithelium was significantly thicker than in the controls and showed an EE dose‐response relation. One of the 16 mice exposed to 0.01 mg/kg/day of EE in utero had cystic or gland‐like structures in the stroma and mucus‐secreting cells in the surface epithelium consisting of columnar cells.