PERMEABILITY OF CAPILLARIES IN VARIOUS ORGANS AS DETERMINED BY USE OF INDICATOR DIFFUSION METHOD
PERMEABILITY OF CAPILLARIES IN VARIOUS ORGANS AS DETERMINED BY USE OF INDICATOR DIFFUSION METHOD
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DOI：
10.1111/j.1748-1716.1963.tb02652.x
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发表时间：
1963-01-01
期刊：
影响因子：
--
通讯作者：
CRONE, C
中科院分区：
文献类型：
--
作者：
CRONE, C
本文提出了定量研究毛细管渗透率的一次进样技术--“指示剂扩散”法的理论。结果表明，毛细血管面积的渗透性可用3个参数表示，即供试品一次注射到流入器官的血液中的初始提取量（E）、血流量（Q）和毛细血管表面积（A）。这些数字的关系式为：P =（Q/A）× loge（1[长划线]E）。本文报道了肾、肝、肺、脑和后肢毛细血管对菊粉和蔗糖的渗透系数。发现毛细血管的渗透性在不同器官之间有很大差异。有人质疑孔隙模型是否充分描述了肌肉中毛细血管的功能特征。孔的存在应导致蔗糖和菊粉的渗透系数之间的比率与自由扩散系数之间的比率的显著偏差。但事实并非如此。
The theory of a single injection technique, the "Indicator Diffusion" method, for quantitative studies of capillary permeability is developed. It is shown that the permeability of a capillary area can be expressed by 3param-eters the initial extraction (E) of test substances added in a single injection to the blood flowing to an organ, the blood flow (Q) and the surface area (A) of the capillaries. The equation relating these figures is: P = (Q/A) x loge(1[long dash]E). The permeability coefficients of capillaries in kidney, liver, lung, brain and hind limb to inulin and sucrose are reported. It is found that the permeability of capillaries varies considerably from organ to organ. It is questioned whether the pore model adequately describes the functional characteristics of the capillaries in the muscles. The existence of pores should result in a pronounced deviation of the ratio between the permeability coefficients for sucrose and inulin from the ratio between the free diffusion coefficients. This was not found to be the case.