Special article "Green Banana" -: Sarcopenia ≠ dynapenia
Special article "Green Banana" -: Sarcopenia ≠ dynapenia
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DOI：
10.1093/gerona/63.8.829
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发表时间：
2008-08-01
影响因子：
5.1
通讯作者：
Manini, Todd M.
中科院分区：
文献类型：
--
作者：
Clark, Brian C.;Manini, Todd M.
最大自愿力量（力量）产生随着年龄的增长而下降，并导致身体依赖和死亡。因此，大量研究集中在确定衰老过程中维持肌肉质量的策略并阐明萎缩的关键分子途径，其基本原理是力量的丧失主要是与年龄相关的质量下降（肌肉减少症）的直接结果。然而，最近的证据对这种关系提出了质疑，在这篇《绿香蕉》文章中，我们认为肌肉减少症在调节与年龄相关的力量丧失（我们将其称为肌肉减少症）方面的作用并不值得科学文献和大众媒体所吸引的关注。相反，我们提出替代机制是缺乏症的基础（即收缩特性或神经功能的改变），并敦促更多地关注这些变量，以确定它们在缺乏症中的作用。
Maximal voluntary force (strength) production declines with age and contributes to physical dependence and mortality. Consequently, a great deal of research has focused on identifying strategies to maintain muscle Mass during the aging process and elucidating key molecular pathways of atrophy, with the rationale that the loss of strength is primarily a direct result of the age-associated declines in mass (sarcopenia). However, recent evidence questions this relationship and in this Green Banana article we argue the role of sarcopenia in mediating the age-associated loss of strength (which we will coin as dynapenia) does not deserve the attention it has attracted in both the scientific literature and popular press. Rather, we propose that alternative mechanisms underlie dynapenia (i.e., alterations in contractile properties or neurologic function), and urge that greater attention be paid to these variables in determining their role in dynapenia.