Developmental stability in house mice heterozygous for single Robertsonian fusions
Developmental stability in house mice heterozygous for single Robertsonian fusions
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DOI：
10.1093/jhered/92.1.23
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发表时间：
2001-01-01
影响因子：
3.1
通讯作者：
Britton-Davidian, J
中科院分区：
文献类型：
--
作者：
Auffray, JC;Fontanillas, P;Britton-Davidian, J
据报道，唐氏综合症患者以及家鼠染色体种族之间的杂种牙齿性状的波动不对称性（FA）在几种罗伯逊（Rb）融合方面有所不同，因此通过FA评估的发育稳定性被认为受到自发染色体异常或染色体杂合性的损害。尽管理论上可以预期单一融合对发育稳定性的影响，但从未有过记录。进行了涉及一种 Rb 融合的两个家鼠染色体种族的杂交，以评估亲本纯合种族及其杂种的发育稳定性。此外，自发染色体突变（WART b 型）的发生使我们能够研究这种易位对发育稳定性的瞬时影响。在本研究中考虑的各组之间没有检测到波动不对称水平的差异。这一结果表明，单一稳定或自发平衡的结构重排本身并不会干扰发育稳定性。此外，一个与多个杂合 Rb 融合体对发育稳定性的不同影响凸显了它们的数量积累在破坏染色体杂种共适应中的作用。
Fluctuating asymmetry (FA) of tooth traits has been reported to be increased in Down syndrome patients as well as hybrids between chromosomal races of the house mouse differing in several Robertsonian (Rb) fusions, Developmental stability, assessed by FA, is thus thought to be impaired by spontaneous chromosomal abnormality or by chromosomal heterozygosity. Although the effect of a single fusion on developmental stability could theoretically be expected, it has never been documented. Crosses involving two chromosomal races of the house mouse diverging for one Rb fusion were performed to assess developmental stability in parental homozygous races as well as in their hybrids. Moreover, the occurrence of a spontaneous chromosomal mutation (WART type-b) allowed us to study the instantaneous effect of such a translocation on developmental stability. No difference in fluctuating asymmetry levels was detected among the groups considered in this study. This result suggested that a single stable or spontaneous balanced structural rearrangement did not inherently disturb developmental stability. In addition, the differential effect on developmental stability of one versus many heterozygous Rb fusions highlights the role of their quantitative accumulation in the disruption of coadaptation in chromosomal hybrids.