Measuring Apathy in Alzheimer's Disease in the Apathy in Dementia Methylphenidate Trial 2 (ADMET 2): A Comparison of Instruments.
Measuring Apathy in Alzheimer's Disease in the Apathy in Dementia Methylphenidate Trial 2 (ADMET 2): A Comparison of Instruments.
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DOI：
10.1016/j.jagp.2020.05.020
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Mintzer JE
中科院分区：
文献类型：
--
作者：
Lanctôt KL;Scherer RW;Li A;Vieira D;Coulibaly H;Rosenberg PB;Herrmann N;Lerner AJ;Padala PR;Brawman-Mintzer O;van Dyck CH;Porsteinsson AP;Craft S;Levey A;Burke WJ;Mintzer JE
冷漠的诊断标准已经公布，但尚未在临床试验中进行评估。痴呆症中的冷漠试验 2 (ADMET 2) 将冷漠诊断标准 (DCA) 纳入临床评级调查问卷中，该调查问卷通过对患者和护理人员的访谈得出。本研究的目的是比较 ADMET 2 中使用 DCA 的冷漠分类与使用神经精神量表冷漠 (NPI-冷漠) 子量表的冷漠分类。还探讨了 NPI-冷漠和痴呆冷漠面谈评级 (DAIR) 量表以及 DCA 和 DAIR 之间的比较。 ADMET 2 是一项随机、双盲、安慰剂对照的 III 期试验，研究 20 毫克/天的哌甲酯对轻至中度 AD 患者 6 个月以上的冷漠症状的影响。招募 NPI-冷漠得分至少为 4 分的参与者。该分析重点关注使用交叉制表的基线冷漠量表得分之间的横截面相关性。在 180 名参与者中，中位年龄为 76.5 岁，他们主要是白人 (92.8%) 和男性 (66.1%)。 NPI 冷漠的平均 (± SD) 得分为 7.7 ± 2.4，DAIR 的平均得分为 1.9 ± 0.5。在 NPI 定义的冷漠患者中，169 人（93.9%，95%CI 89.3%−96.9%）符合 DCA 诊断标准。 DCA 和 DAIR 对 169 名参与者的冷漠诊断有重叠（93.9%，95%CI 89.3%−96.9%）。用于评估 AD 患者冷漠程度的测量方法与 DCA 高度重叠。用于确定 ADMET 2 中冷漠的 NPI-冷漠截止值选择那些可能满足 DCA 标准的人。
Diagnostic criteria for apathy have been published but have yet to be evaluated in the context of clinical trials. The Apathy in Dementia Methylphenidate Trial 2 (ADMET 2) operationalized the diagnostic criteria for apathy (DCA) into a clinical-rated questionnaire informed by interviews with the patient and caregiver. The goal of the present study was to compare the classification of apathy using the DCA with that using the Neuropsychiatric Inventory-apathy (NPI-apathy) subscale in ADMET 2. Comparisons between NPI-Apathy and Dementia Apathy Interview Rating (DAIR) scale, and DCA and DAIR were also explored. ADMET 2 is a randomized, double-blind, placebo-controlled phase III trial examining the effects of 20mg/day methylphenidate on symptoms of apathy over 6 months in patients with mild to moderate AD. Participants scoring at least 4 on the NPI-Apathy were recruited. This analysis focuses on cross-sectional correlations between baseline apathy scale scores using cross-tabulation. Of 180 participants, the median age was 76.5 years and they were predominantly white (92.8%) and male (66.1%). The mean (± SD) scores were 7.7 ± 2.4 on the NPI-apathy, and 1.9 ± 0.5 on the DAIR . Of those with NPI-defined apathy, 169 (93.9%, 95%CI 89.3%−96.9%) met DCA diagnostic criteria. The DCA and DAIR overlapped on apathy diagnosis for 169 participants (93.9%, 95%CI 89.3%−96.9%). The measurements used for the assessment of apathy in patients with AD had a high degree of overlap with the DCA. The NPI-apathy cut-off used to determine apathy in ADMET 2 selects those likely to meet DCA criteria.
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影响因子：
2.4
作者：
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通讯作者：
Byrne, Eleanor Jane
影响因子：
4.7
作者：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1016/j.jalz.2011.01.007
发表时间：
2012
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Drye LT;Ismail Z;Porsteinsson AP;Rosenberg PB;Weintraub D;Marano C;Pelton G;Frangakis C;Rabins PV;Munro CA;Meinert CL;Devanand DP;Yesavage J;Mintzer JE;Schneider LS;Pollock BG;Lyketsos CG;CitAD Research Group
通讯作者：
CitAD Research Group
影响因子：
4
作者：
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