Anaemia in the first but not in the second or third trimester is a risk factor for low birth weight
Anaemia in the first but not in the second or third trimester is a risk factor for low birth weight
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DOI：
10.1016/s0261-5614(02)00209-1
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发表时间：
2003-06-01
影响因子：
6.3
通讯作者：
Heinonen, S
中科院分区：
文献类型：
--
作者：
Hämäläinen, H;Hakkarainen, K;Heinonen, S
目的：评估怀孕期间患有贫血的妇女的妊娠结局。方法：研究设计对 1990 年至 2000 年间在库奥皮奥大学医院地区登记进行产前护理的所有妇女进行回顾性图表审查。血红蛋白浓度低于 100 g/l 被用作贫血的临界值，受影响的妇女 (N=597) 按诊断贫血的三个月期进行分层。采用多元回归分析比较研究组和非贫血女性 (N=22,202) 的产科结果。结果：贫血发生率为 2.6%，其中 0.3% 发生在妊娠早期。控制混杂因素后，妊娠早期检测到的贫血与低出生体重婴儿相关（OR=3.14，95% Cl：1.35-7.28），而妊娠中期和晚期贫血组与非贫血女性相比，结果没有显着差异。早孕期贫血与低出生体重（OR=0.98，95% Cl：0.41-217）或早产 < 37 周（OR=1.80，95% Cl：0.72-4.49）没有显着相关性。 结论：早孕期检测到的母亲贫血与低出生体重相关。 (C) 2003 Elsevier Science Ltd. 保留所有权利。
Objective: To assess pregnancy outcome in women with anaemia during pregnancy.Methods: The study design involved a retrospective chart review of all women registering for prenatal care in the area of Kuopio University Hospital between 1990 and 2000. A haemoglobin concentration below 100 g/l was used as a cutoff for anaemia and affected women (N=597) were stratified by the trimester at which anaemia was diagnosed. Multiple regression analysis was used to compare obstetric outcomes in the study groups and in non-anaemic women (N=22,202).Results: The frequency of anaemia was 2.6%, with 0.3% occurring in the first trimester. After controlling for confounding factors, anaemia detected in the first trimester was associated with low-birth-weight infants (OR=3.14,95% Cl: 1.35-7.28) whereas the mid- and third-trimester anaemia groups showed no significantly different outcomes when compared with the non-anaemic women. First trimester anaemia was not significantly associated with small birth weight for gestational age (OR=0.98, 95% Cl: 0.41-217) or with premature delivery < 37 weeks (OR=1.80, 95% Cl: 0.72-4.49).Conclusions: Maternal anaemia detected in the first trimester is associated with low birth weight. (C) 2003 Elsevier Science Ltd. All rights reserved.