Two peaks of interleukin 1 expression in human leukocytes cultured with tobacco glycoprotein.
Two peaks of interleukin 1 expression in human leukocytes cultured with tobacco glycoprotein.
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DOI：
10.1084/jem.170.1.327
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发表时间：
1989-07-01
期刊：
影响因子：
--
通讯作者：
Szabo P
中科院分区：
文献类型：
--
作者：
Francus T;Manzo G;Canki M;Thompson LC;Szabo P
We have previously shown that tobacco glycoprotein (TGP), a polyphenol- rich glycoprotein isolated from tobacco or from cigarette smoke, affects the immune system. In this study we show that TGP induces human PBL and adherent cells to produce IL-1 alpha and IL-1 beta. Two peaks of IL-1 activity were observed; one at 18-24 h, the second at 4-6 d after initiation of culture. A similar pattern was observed for the steady state level of IL-1 mRNA. These data suggest that the production of IL-1 by cells stimulated with TGP might be a factor in cardiovascular disease associated with cigarette smoking.
