The contributory role of lymphocyte subsets, pathophysiology of lymphopenia and its implication as prognostic and therapeutic opportunity in COVID-19.
The contributory role of lymphocyte subsets, pathophysiology of lymphopenia and its implication as prognostic and therapeutic opportunity in COVID-19.
复制标题
淋巴细胞亚群的贡献作用，淋巴细胞减少症的病理生理学及其作为COVID-19预后和治疗机会的意义。
DOI：
10.1016/j.intimp.2021.107586
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发表时间：
2021-06
影响因子：
5.6
通讯作者：
Bashash D
中科院分区：
文献类型：
--
作者：
Delshad M;Tavakolinia N;Pourbagheri-Sigaroodi A;Safaroghli-Azar A;Bagheri N;Bashash D
由严重急性呼吸道综合征冠状病毒2型（SARS-CoV-2）引起的新型冠状病毒病（COVID-19）爆发的发病率给世界各地的人们和医生带来了令人生畏的并发症。越来越多的研究调查这种疾病的特征，日复一日，揭示了这种病毒的一个新特征，希望最终这些努力导致适当的治疗。SARS-CoV-2激活抗病毒免疫反应，但此外可能过度产生促炎细胞因子，导致严重COVID-19患者出现不受控制的炎症反应。这种情况可能导致淋巴细胞减少症和淋巴细胞功能障碍，这反过来又使患者易于进一步感染、感染性休克和严重的多器官功能障碍。因此，对这一问题的准确认识对于指导该疾病的临床管理和COVID-19患者新治疗策略的开发非常重要。在这篇综述中，我们提供了一个有价值的信息，改变每个亚型的淋巴细胞和重要的预后因素与这些细胞。此外，通过讨论淋巴细胞减少症的病理生理学和讨论COVID-19患者中一些最新的淋巴细胞或淋巴细胞减少症相关的治疗策略，我们试图为COVID-19患者，特别是那些患有严重疾病的患者，带来可预见的未来。
The incidence of the novel coronavirus disease (COVID-19) outbreak caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has brought daunting complications for people as well as physicians around the world. An ever-increasing number of studies investigating the characteristics of the disease, day by day, is shedding light on a new feature of the virus with the hope that eventually these efforts lead to the proper treatment. SARS-CoV-2 activates antiviral immune responses, but in addition may overproduce pro-inflammatory cytokines, causing uncontrolled inflammatory responses in patients with severe COVID-19. This condition may lead to lymphopenia and lymphocyte dysfunction, which in turn, predispose patients to further infections, septic shock, and severe multiple organ dysfunction. Therefore, accurate knowledge in this issue is important to guide clinical management of the disease and the development of new therapeutic strategies in patients with COVID-19. In this review, we provide a piece of valuable information about the alteration of each subtype of lymphocytes and important prognostic factors associated with these cells. Moreover, through discussing the lymphopenia pathophysiology and debating some of the most recent lymphocyte- or lymphopenia-related treatment strategies in COVID-19 patients, we tried to brightening the foreseeable future for COVID-19 patients, especially those with severe disease.
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影响因子：
158.5
作者：
Cao, B.;Wang, Y.;Wang, C.
通讯作者：
Wang, C.
影响因子：
1.5
作者：
Chhetri, Shabnam;Khamis, Faryal;Petersen, Eskild
通讯作者：
Petersen, Eskild
DOI：
10.1016/j.transci.2020.102955
发表时间：
2021-03
期刊：
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis
影响因子：
--
作者：
Altuntas F;Ata N;Yigenoglu TN;Bascı S;Dal MS;Korkmaz S;Namdaroglu S;Basturk A;Hacıbekiroglu T;Dogu MH;Berber İ;Dal K;Kınık K;Haznedaroglu İ;Yılmaz FM;Kılıç İ;Demircioğlu S;Yosunkaya A;Erkurt MA;Turgut B;Caglayan M;Celik O
通讯作者：
Celik O
影响因子：
5.4
作者：
Cheung, CY;Poon, LLM;Peiris, JSM
通讯作者：
Peiris, JSM
影响因子：
14.3
作者：
Bonam, Srinivasa Reddy;Kaveri, Srini, V;Bayry, Jagadeesh
通讯作者：
Bayry, Jagadeesh