Consecutive Intake of Fermented Milk Containing Bifidobacterium breve Strain Yakult and Galacto-oligosaccharides Benefits Skin Condition in Healthy Adult Women.
Consecutive Intake of Fermented Milk Containing Bifidobacterium breve Strain Yakult and Galacto-oligosaccharides Benefits Skin Condition in Healthy Adult Women.
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DOI：
10.12938/bmfh.32.33
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Ishikawa F
中科院分区：
文献类型：
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作者：
Kano M;Masuoka N;Kaga C;Sugimoto S;Iizuka R;Manabe K;Sone T;Oeda K;Nonaka C;Miyazaki K;Ishikawa F
进行了一项双盲、安慰剂对照、随机试验，以研究益生菌和益生元发酵奶对健康成年女性皮肤的有益作用。四十名健康皮肤健康的日本成年女性志愿者每天随机服用一瓶含有短双歧杆菌益力多菌株和低聚半乳糖（GOS）的益生菌和益生元发酵奶（活性组）或不含益生菌和GOS的非发酵安慰剂奶（安慰剂组），持续4周。摄入前后，测定角质层中的水合水平和组织蛋白酶L样活性以及血清和尿液中的苯酚水平。摄入后，仅安慰剂组的角质层水合水平显着下降，并且显着低于活性组（p=0.031）。组织蛋白酶 L 样活性（角质形成细胞分化的指标）在活性组中显着增加（p=0.027）。活性组的血清和尿液酚水平显着降低（分别为p=0.014，p=0.002），与安慰剂组相比，活性组的血清酚水平显着降低（p=0.006）。连续摄入益生菌和益生元发酵乳可以改善健康成年女性的皮肤状况而不干燥，并降低肠道细菌产生苯酚的水平。
A double-blind, placebo-controlled, randomized trial was conducted to investigate the beneficial effect of probiotic and prebiotic fermented milk on the skin of healthy adult women. Forty healthy Japanese adult female volunteers with healthy skin randomly received either a bottle of probiotic and prebiotic fermented milk containing Bifidobacterium breve strain Yakult and galacto-oligosaccharides (GOS) (active group) or a non-fermented placebo milk containing neither probiotics nor GOS (placebo group) daily for 4 weeks. Before and after intake, hydration levels and cathepsin L-like activity in the stratum corneum and phenol levels in the serum and urine were determined. After intake, the hydration level of the stratum corneum decreased significantly in only the placebo group and was significantly lower than in the active group (p=0.031). Cathepsin L-like activity, an indicator of keratinocyte differentiation, was significantly increased in the active group (p=0.027). Serum and urine phenol levels decreased significantly in the active group (p=0.014, p=0.002, respectively), and serum phenol levels were significantly lower in the active group compared with the placebo group (p=0.006). The consecutive intake of probiotic and prebiotic fermented milk can benefit skin condition without dryness and decrease the levels of phenol production by gut bacteria in healthy adult women.