Cross-talk between the immune and endocrine systems.
Cross-talk between the immune and endocrine systems.
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DOI：
10.2527/jas1988.6682095x
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发表时间：
1988-08
影响因子：
3.3
通讯作者：
Keith W. Kelley
中科院分区：
文献类型：
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作者：
Keith W. Kelley
自从Selye发现急性应激源减少淋巴器官的大小以来，免疫生理学领域取得了重大进展。已知除糖皮质激素以外的多种激素影响淋巴样细胞和巨噬细胞的功能活性。本文综述了糖皮质激素等激素对家畜淋巴细胞影响的最新研究结果。糖皮质激素和β-肾上腺素能受体在活化的淋巴细胞上上调。经典的垂体激素是由淋巴细胞合成的，生长激素和催乳素似乎都有不同的免疫调节作用。此外，淋巴细胞的某些活动可能是行为条件。这些发现支持了内分泌系统的变化影响淋巴细胞的假设。他们还认为免疫系统的产物会影响内分泌系统。这些发现为这两个生理系统之间的串扰的可能性提供了坚实的功能基础。
Significant advances have been made in the field of immunophysiology since Selye discovered that acute stressors reduce the size of lymphoid organs. It is known that a variety of hormones other than glucocorticoids affect functional activities of lymphoid cells and macrophages. This paper summarizes recent findings of the effects of glucocorticoids and other hormones on lymphoid cells of domestic animals. Glucocorticoid and beta-adrenergic receptors are up-regulated on activated lymphoid cells. Classic pituitary hormones are synthesized by lymphoid cells, and both growth hormone and prolactin appear to have distinct roles as immunomodulators. In addition, certain activities of lymphoid cells may be behaviorally conditioned. These findings support the hypothesis that changes in the endocrine system affect lymphoid cells. They also suggest that products of the immune system affect the endocrine system. These findings provide a firm functional basis for the possibility of cross-talk between these two physiological systems.