Role of microglia in inflammation-mediated neurodegenerative diseases: Mechanisms and strategies for therapeutic intervention
Role of microglia in inflammation-mediated neurodegenerative diseases: Mechanisms and strategies for therapeutic intervention
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DOI：
10.1124/jpet.102.035048
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发表时间：
2003-01-01
影响因子：
3.5
通讯作者：
Hong, JS
中科院分区：
文献类型：
--
作者：
Liu, B;Hong, JS
尸检分析的证据表明，小胶质细胞参与了几种退行性神经系统疾病的神经退行性过程，包括阿尔茨海默病和帕金森病。然而，小胶质细胞活化是否在疾病进展的起始阶段起作用或仅仅作为对神经元死亡的反应而发生，仍有待确定。活化的小胶质细胞分泌多种促炎因子和神经毒性因子，这些因子被认为诱导和/或加剧神经变性。在这篇文章中，我们总结了最近的研究进展的基础上，从动物和细胞培养模型的神经退行性疾病的发病机制，特别是帕金森氏病的小胶质细胞的作用。此外，我们还讨论了潜在的治疗策略的新方法。
Evidence from postmortem analysis implicates the involvement of microglia in the neurodegenerative process of several degenerative neurological diseases, including Alzheimer's disease and Parkinson's disease. It remains to be determined, however, whether microglial activation plays a role in the initiation stage of disease progression or occurs merely as a response to neuronal death. Activated microglia secrete a variety of proinflammatory and neurotoxic factors that are believed to induce and/or exacerbate neurodegeneration. In this article, we summarize recent advances on the study of the role of microglia based on findings from animal and cell culture models in the pathogenesis of neurodegenerative diseases, with particular emphasis on Parkinson's disease. In addition, we also discuss novel approaches to potential therapeutic strategies.