Acute and chronic effects of alcohol exposure on skeletal muscle c-myc, p53, and Bcl-2 mRNA expression
Acute and chronic effects of alcohol exposure on skeletal muscle c-myc, p53, and Bcl-2 mRNA expression
复制标题
DOI：
10.1152/ajpendo.00019.2003
复制
发表时间：
2003-12-01
影响因子：
5.1
通讯作者：
Preedy, VR
中科院分区：
文献类型：
--
作者：
Nakahara, T;Hashimoto, K;Preedy, VR
骨骼肌萎缩是酒精中毒的一个常见特征，影响了多达三分之二的酒精滥用者，女性似乎特别容易受到影响。还有一些证据表明，营养不良加剧了酒精对肌肉的影响。然而，负责肌病的机制仍然难以捉摸，一些研究表明，乙醛，而不是酒精，是主要的致病扰动。先前关于大鼠急性服用乙醇的报告（
Skeletal muscle atrophy is a common feature in alcoholism that affects up to two-thirds of alcohol misusers, and women appear to be particularly susceptible. There is also some evidence to suggest that malnutrition exacerbates the effects of alcohol on muscle. However, the mechanisms responsible for the myopathy remain elusive, and some studies suggest that acetaldehyde, rather than alcohol, is the principal pathogenic perturbant. Previous reports on rats dosed acutely with ethanol (