Differential channelling of liver lipids in relation to susceptibility to hepatic steatosis in the goose
Differential channelling of liver lipids in relation to susceptibility to hepatic steatosis in the goose
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DOI：
10.1093/ps/78.10.1398
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发表时间：
1999-10-01
期刊：
影响因子：
4.4
通讯作者：
Peresson, R
中科院分区：
文献类型：
--
作者：
Hermier, D;Salichon, MR;Peresson, R
为了生产“鹅肝”而过度喂食，波兰鹅与朗德鹅的不同之处在于对肝脂肪变性的敏感性较低，导致肝三酰甘油（TG）的积累较低，以及极低密度脂蛋白（VLDL）和高密度脂蛋白（HDL）中肝磷脂（PL）的输出较多（Fournier et al.，1997年）。设计了一项研究，1）比较两种鹅的过度饲养和非过度饲养鹅的肝脏组成，2）确定响应于过度饲养的脂质的差异通道是否反映在不同肝脏脂质（无论是储存的还是分泌的）的PL和脂肪酸谱中。在nonoverfeed鹅，有没有品种相关的差异，肝脏重量（类似90至100克），肝脏脂质含量（3至4%），脂质和PL组成。然而，血浆极低密度脂蛋白和高密度脂蛋白的兰德斯品种含有较高的磷脂酰胆碱（PC），磷脂酰乙醇胺（PE）比的波兰品种（20.7和33.8对12.6和25.6极低密度脂蛋白和高密度脂蛋白，分别）。14天的过度饲养后，肝脏PL的配置文件是相同的，在两个品种和类似的控制肝脏;含胆碱PL占总FL的95%。相反，血浆HDL浓度的朗德鹅低于那些波兰鹅（9.4比12.9 g/L）和PC：PE（13.6%）和PL-多不饱和脂肪酸（PUFA）含量（25%）下降相比，波兰鹅（21.2和30%）。这可能是因为兰德斯品种对脂肪肝的易感性更高，涉及FL的差异通道，导致质膜生长和细胞肥大所必需的PC和PUFA在肝脏中的滞留更大。
In response to overfeeding for the production of "foie gras," the Poland goose differs from the Landes goose by a lesser susceptibility to hepatic steatosis, resulting in a lower accumulation of hepatic triacylglycerol (TG), together with a greater exportation of hepatic phospholipid (PL) in very low density lipoproteins (VLDL) and high density Lipoproteins (HDL) (Fournier et al., 1997). A study was designed 1) to compare the liver composition in overfed and nonoverfed geese of the two breeds of geese and 2) to determine whether the differential channelling of Lipids in response to overfeeding is reflected in the PL and fatty acid profiles of the different hepatic lipids, whether stored or secreted. In nonoverfed geese, there were no breed-related differences in Liver weight (similar to 90 to 100 g), hepatic Lipid content (3 to 4%), and lipid and PL composition. However, plasma VLDL and HDL of the Landes breed contained a higher phosphatidylcholine (PC) to phosphatidylethanolamine (PE) ratio than those of the Poland breed (20.7 and 33.8 vs 12.6 and 25.6 in VLDL and HDL, respectively). After 14 d of overfeeding, hepatic PL profiles were identical in the two breeds and similar to that in control livers; choline-containing PL accounted for 95% of total FL. In contrast, plasma HDL concentrations of the Landes geese were lower than those of the Poland geese (9.4 vs 12.9 g/L) and their PC:PE (13.6%) and PL-polyunsaturated fatty acids (PUFA) content (25%) were decreased compared with the Poland geese (21.2 and 30%). It is likely that the higher susceptibility to fatty liver of the Landes breed involves a differential channelling of FL, resulting in a greater hepatic retention of PC and PUFA that are necessary for plasma membrane growth and cell hypertrophy.