Psammaplin A, a natural bromotyrosine derivative from a sponge, possesses the antibacterial activity against methicillin-resistant Staphylococcus aureus and the DNA gyrase-inhibitory activity
Psammaplin A, a natural bromotyrosine derivative from a sponge, possesses the antibacterial activity against methicillin-resistant Staphylococcus aureus and the DNA gyrase-inhibitory activity
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DOI：
10.1007/bf02976431
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发表时间：
1999-02-01
影响因子：
6.7
通讯作者：
Yang, SI
中科院分区：
文献类型：
--
作者：
Kim, DY;Lee, IS;Yang, SI
Psammaplin A是来自两种海绵（Poecillastra sp.和Jaspis sp.）对革兰氏阳性菌，尤其是耐甲氧西林金黄色葡萄球菌（MRSA）有一定的抗菌作用。21株MRSA的最低抑菌浓度为0.781 ~ 6.25 μ g/ml，环丙沙星为0.391 ~ 3.125 μ g/ml。Psammaplin A不与青霉素结合蛋白结合，但抑制DNA合成和DNA促旋酶活性，其50%（DNA合成）和100%（DNA促旋酶）抑制浓度分别为2.83和100 μ g/ml。这些结果表明，psammaplin A具有相当大的抗菌活性，尽管仅限于较窄范围的细菌，可能是通过抑制DNA促旋酶。
Psammaplin A, a natural bromotyrosine derivative from an associated form of two sponges (Poecillastra sp. and Jaspis sp.) was found to possess the antimicrobial effect on the Gram-positive bacteria, especially on methicillin-resistant Staphylococcus aureus (MRSA). The minimal inhibitory concentration of psammaplin A against twenty one MRSAs ranged from 0.781 to 6.25 mu g/ml, while that of ciprofloxacin was 0.391 similar to 3.125 mu g/ml. Psammaplin A could not bind to penicillin binding protein, but inhibited the DNA synthesis and the DNA gyrase activity with the respective 50% (DNA synthesis) and 100% (DNA gyrase) inhibitory concentration 2.83 and 100 mu g/ml. These results indicate that psammaplin A has a considerable antibacterial activity, although restricted to a somewhat narrow range of bacteria, probably by inhibiting DNA gyrase.