DIAGNOSIS OF PROTEIN-LOSING ENTEROPATHY BY GASTROINTESTINAL CLEARANCE OF ALPHA-1-ANTITRYPSIN
DIAGNOSIS OF PROTEIN-LOSING ENTEROPATHY BY GASTROINTESTINAL CLEARANCE OF ALPHA-1-ANTITRYPSIN
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DOI：
10.1016/s0140-6736(78)92650-8
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发表时间：
1978-01-01
期刊：
影响因子：
168.9
通讯作者：
LHIRONDEL, C
中科院分区：
文献类型：
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作者：
BERNIER, JJ;FLORENT, C;LHIRONDEL, C
对10例蛋白缺失性肠病患者和13例对照组进行了α1-抗胰蛋白酶检测，作为血浆蛋白丢失进入胃肠道的内源性标志物。患者组的fæcalα1-A.T.浓度和fæcalα1-A.T.清除率均显著高于对照组。在清除的情况下，两组之间没有重叠。在10天以上，α1-A.T.的正常胃肠清除量为3.07±2.25(S.D.)毫升/天。α1-A.T.清除量的测量很容易，而且不需要放射性同位素。
Alpha1-antitrypsin was assessed, in 10 patients with protein-losing enteropathy and 13 control subjects, as an endogenous marker of plasma-protein loss into the gastrointestinal tract. Both fæcal α1-A.T. concentrations and fæcal α1-A.T. clearance were significantly higher in patients than in controls. With clearance there was no overlap between the groups. Over 10 days the normal gastrointestinal clearance of α1-A.T. was 3·07±2·25 (S.D.) ml/day. Measurement of α1-A.T. clearance is easy and requires no radioisotopes.