Cardiac hypertrophy in hypertension: relation to 24-h blood pressure profile and arterial stiffness.
Cardiac hypertrophy in hypertension: relation to 24-h blood pressure profile and arterial stiffness.
复制标题
高血压引起的心脏肥大：与 24 小时血压曲线和动脉僵硬度的关系。
DOI：
10.1016/j.ijcard.2003.06.011
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发表时间：
2004
影响因子：
3.5
通讯作者：
M. Mavrikakis
中科院分区：
文献类型：
--
作者：
J. Lekakis;N. Zakopoulos;A. Protogerou;V. Kotsis;T. Papaioannou;K. Stamatelopoulos;Marios D Tsitsiricos;V. Pitiriga;C. Papamichael;S. Toumanides;M. Mavrikakis
背景：原发性高血压患者外周血压变化与左心室肥厚的发病机制有关。目前尚不清楚中央动脉压是否优于外周血压预测左心室肥厚。在本研究中，研究人员检查了24小时血压曲线和中央血流动力学，以评估机械负荷因素是轻度至中度未经治疗的原发性高血压患者心脏肥厚的决定因素。方法对48例轻中度原发性高血压患者进行超声心动图评价左室质量、24小时动态血压监测（ABPM）和桡动脉压平压压仪结合脉搏波分析评价中央血流动力学。结果左室质量与年龄、临床收缩压、24h ABPM平均心率和心率变异性、增压压和增压指数、中心收缩压均有统计学意义。在包括临床收缩压、中心收缩压、平均收缩压和脉搏压以及年龄在内的多元回归分析中，左心室质量的独立预测因子只有年龄（P=0.006）和中心收缩压（P=0.04）。总之，脉搏波分析是预测未经治疗的轻中度原发性高血压患者心脏肥厚的一种有价值的方法。在制定预防高血压患者左心室肥厚的治疗策略时，应考虑到中央收缩压。
BackgroundIn subjects with essential hypertension peripheral blood pressure profile contributes to the pathogenesis of left ventricular hypertrophy. It is not known if central arterial pressure is superior to peripheral blood pressure profile for predicting left ventricular hypertrophy. In the present study 24-h blood pressure profile and central hemodynamics were examined to evaluate mechanical loading factors as determinants of cardiac hypertrophy in mild to moderate untreated essential hypertension.MethodsForty-eight untreated subjects with mild to moderate essential hypertension were examined by echocardiography for evaluation of left ventricular mass, 24-h ambulatory blood pressure monitoring (ABPM), and applanation tonometry of the radial artery with pulse wave analysis for evaluation of central hemodynamics.ResultsLeft ventricular mass showed a statistically significant correlation with age, clinic systolic blood pressure, mean heart rate and heart rate variability during 24-h ABPM, augmentation pressure and index and central systolic blood pressure. In a multiple regression analysis including clinic systolic blood pressure, central systolic pressure, mean systolic pressure and pulse pressure during ambulatory monitoring as well as age, independent predictors of left ventricular mass were only age (P=0.006) and central systolic blood pressure (P=0.04). In conclusion, pulse wave analysis is a valuable method in predicting cardiac hypertrophy in untreated mild to moderate essential hypertension. Central systolic blood pressure should be taken into account for planning therapeutic strategies for prevention of left ventricular hypertrophy in hypertensive patients.
影响因子：
37.8
作者：
Chen-Huan Chen-Chen-Huan-Chen-10355153;E. Nevo;B. Fetics;P. Pak;F. Yin;W. Maughan;D. Kass
通讯作者：
Chen-Huan Chen-Chen-Huan-Chen-10355153;E. Nevo;B. Fetics;P. Pak;F. Yin;W. Maughan;D. Kass
影响因子：
39.2
作者：
KOREN, MJ;DEVEREUX, RB;LARAGH, JH
通讯作者：
LARAGH, JH