Selective nanoscale positioning of ferritin and nanoparticles by means of target-specific peptides
Selective nanoscale positioning of ferritin and nanoparticles by means of target-specific peptides
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DOI：
10.1002/smll.200600220
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发表时间：
2006-10-01
期刊：
影响因子：
13.3
通讯作者：
Mishima, Yumiko
中科院分区：
文献类型：
--
作者：
Yamashita, Khiro;Kirimura, Hiroya;Mishima, Yumiko
许多研究人员和科学家最近对纳米颗粒（NPs）感兴趣，因为它们巨大的表面积与体积比赋予它们前所未有的，复杂的和有用的特性，而这些特性是散装材料无法实现的。已经研究了许多生产NP的方法，从物理到化学和生物。在笼状蛋白质的空腔中的NP合成最近受到了极大的关注，因为蛋白质空腔的大小是可再现地相同的，并且在这些空间受限的化学反应室中合成和完全发育的NP也应该具有相同的大小。在许多种类的笼状蛋白质分子中，研究最多的是铁蛋白。铁蛋白是一种普遍存在的铁储存蛋白，具有由24个亚基组成的球形中空外壳（脱铁铁蛋白）和一个水铁矿核心。[1，2]铁蛋白蛋白壳的外径和内径分别约为12 nm和7 nm，并且有多种无机纳米颗粒，包括Co3 O4，[3，4]
Many researchers and scientists have recently been intrigued by nanoparticles (NPs) because their immense surface-to-volume ratio bestows on them unprecedented, sophisticated, and useful properties that cannot be attained by bulk materials. Numerous methods of producing NPs have been studied, ranging from the physical to the chemical and the biological. NP synthesis in the cavity of cage-shaped proteins has recently received a great deal of attention because the size of the protein cavity is reproducibly identical and NPs synthesized and fully developed in these spatially confined chemical reaction chambers should also be of the same size. Of the many kinds of cage-shaped protein molecules, the most studied has been ferritin. Ferritin is a ubiquitous iron-storage protein and has a spherical hollow shell (apoferritin) composed of 24subunits and a ferrihydrite core.[1, 2] The outer and inner diameters of the ferritin protein shell are approximately 12 nm and 7 nm, respectively, and many kinds of inorganic NPs, including Co3O4,[3, 4]