Triglyceride profiles are associated with subacute exposure to bisphenol A in healthy young adults
Triglyceride profiles are associated with subacute exposure to bisphenol A in healthy young adults
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健康年轻人的甘油三酯谱与亚急性接触双酚 A 相关
DOI：
10.1016/j.scitotenv.2022.153991
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发表时间：
2022
影响因子：
9.8
通讯作者：
Yifang Zhu
中科院分区：
文献类型：
--
作者：
Xinchen Lu;Yan Lin;Xinghua Qiu;Jinming Liu;Tong Zhu;Jesus A. Araujo;Oliver Fiehn;Yifang Zhu
从以前的流行病学研究中得出的结论要求将双酚A（BPA）暴露与心脏代谢疾病联系起来的机制证据。在这项自然实验中，我们在从洛杉矶（LA）到北京的健康旅行者中收集了他们出发前、到达北京后6-8周和返回LA后4-7周的配对尿液和血液样本，用于评估尿液BPA和血液血清组分中的脂质体，研究BPA暴露量急剧变化对脂质代谢的影响，与心脏代谢紊乱的发展有关。我们使用线性混合效应模型，随机截取参与者和阶段，以检查尿BPA和血清脂质组之间的关联。在来自七个类别的744种脂质中，甘油三酯（TG）与BPA暴露的关联最强。BPA暴露的升高与短碳链或很少双键的TG增加有关，而长碳链或许多双键的TG减少。BPA相关的TG变化与酰基链中的碳数和双键数之间存在显著的线性关系。BPA暴露和TG之间的关联没有观察到性别的修改效果，但体重指数（BMI）。这项跨学科的环境研究根据TG谱的扰动证实了BPA的心脏代谢作用。
Conflicted results from previous epidemiological studies call for mechanistic evidence to associate exposure to bisphenol A (BPA) with cardiometabolic diseases. In this natural experiment among healthy travelers from Los Angeles (LA) to Beijing, we collected paired urine and blood samples before their departure, 6–8 weeks after their arrival to Beijing, and 4–7 weeks after their return to LA for the assessment of urinary BPA and lipidome in the serum fraction of blood, to study the effects of drastically changed BPA exposure on the lipid metabolism in relation to the development of cardiometabolic disorders. We used linear mixed-effects models with random intercepts for participant and phase to examine the associations between urinary BPA and serum lipidome. Among 744 lipid species from seven classes, triglyceride (TGs) species showed the strongest associations with BPA exposure. The elevation in BPA exposure was associated with increases in TGs with short carbon chains or few double bonds, and decreases in TGs with long carbon chains or many double bonds. A significant linear relationship was observed between BPA-associated TG changes and the number of carbons and double-bonds in the acyl chain. No modification effects of gender but of body mass index (BMI) were observed on the associations between BPA exposure and TGs. This interdisciplinary environmental research substantiated the cardiometabolic effects of BPA according to the perturbations of TG profiling.