THE MOLECULAR-WEIGHT OF SODIUM HYALURONATE IN AMNIOTIC-FLUID
THE MOLECULAR-WEIGHT OF SODIUM HYALURONATE IN AMNIOTIC-FLUID
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DOI：
10.1016/0885-4505(86)90077-0
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发表时间：
1986-04-01
期刊：
影响因子：
--
通讯作者：
BORRESEN, AL
中科院分区：
文献类型：
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作者：
DAHL, LB;DAHL, IMS;BORRESEN, AL
用凝胶色谱法测定了人羊水中透明质酸钠的分子量。从妊娠16周收集的样本显示出广泛的分子量分布（Mw = 3倍）。105年;Mn = 6。104)。40周时采集的样本显示低分子量部分（M < 105）可能是胎儿起源，而高分子量部分（M < 106）变化很大，表明非胎儿起源。液体中未检测到透明质酸降解活性。在一个肾发育不良的病例中，仅发现微量的透明质酸。这些发现与胎儿肾排泄低分子量透明质酸一致。在12例证实神经管缺陷的病例中，透明质酸水平和分子量与正常对照组相比无显著差异。
The molecular weight of sodium hyaluronate in human amniotic fluid was determined by gel chromatography. Pooled samples from 16 weeks of gestation exhibited a broad molecular weight distribution (Mw = 3 .times. 105; Mn = 6 .times. 104). Samples taken at 40 weeks showed a low molecular weight fraction (M < 105) presumably of fetal origin, and a high molecular weight fraction (M > 106) which varied considerably, indicating a nonfetal origin. No hyaluronate degrading activity was detected in the fluid. In a case of renal dysplasia, only minute amounts of hyaluronate were found. These findings are in accordance with a renal excretion of a low molecular weight hyaluronate from the fetus. In 12 cases with proven neural tube defects, there was no significant difference in hyaluronate level and molecular weight compared to normal controls.