The response of hair cells in the basal turn of the guinea‐pig cochlea to tones.
The response of hair cells in the basal turn of the guinea‐pig cochlea to tones.
复制标题
豚鼠耳蜗基底转毛细胞对音调的反应。
DOI：
10.1113/jphysiol.1987.sp016428
复制
发表时间：
1987
期刊：
影响因子：
--
通讯作者：
I. Russell
中科院分区：
文献类型：
--
作者：
A. Cody;I. Russell
1.从豚鼠耳蜗基底回的内毛细胞和外毛细胞进行细胞内记录。内毛细胞的静息膜电位大于-50 mV，而外毛细胞的静息膜电位通常大于-70 mV。2.在低频率下，内毛细胞的受体电位主要是去极化的，而外毛细胞的受体电位在低和中等声压下（例如，在600 Hz下小于90 dB re 2 X 10（-5）Pa）是超极化的。然后，电位在高声压下变得主要去极化。3.内毛细胞和外毛细胞受体电位的不对称性是瞬间表现出来的，除了在高刺激水平时，外毛细胞的去极化反应需要几个周期来发展。4.在强音调的偏移下，外毛细胞膜电位保持去极化，比其静息值高1 - 2 mV，并在一段时间内恢复正常，这取决于音调的水平和持续时间。5.对于高于约2kHz和低于约90dB的音调，外毛细胞感受器电位的波形实际上是对称的，没有可测量的直流分量。为了响应接近其最佳频率（16 - 21 kHz）的音调，基底匝中的内毛细胞产生大的去极化（d.c.）感受器电位，而来自耳蜗的该区域的外毛细胞不产生显著的电压响应。6.频率调谐曲线从内毛细胞和外毛细胞的d.c.和相位（a.c.）受体电位。当后者补偿记录系统的低通特性和毛细胞时间常数时，内毛细胞和外毛细胞的频率选择性相似。7.内和外毛细胞的反应特性在豚鼠耳蜗的基底回的讨论有关他们提出的作用在机电转导。
1. Intracellular recordings were made from inner and outer hair cells in the basal turn of the guinea‐pig cochlea. The resting membrane potentials of the inner hair cells are more positive than ‐50 mV while those of outer hair cells are usually more negative than ‐70 mV. 2. At low frequencies the receptor potentials of inner hair cells are predominantly depolarizing while those from outer hair cells are hyperpolarizing at low and moderate sound pressure (e.g. less than 90 dB re 2 X 10(‐5) Pa at 600 Hz). The potentials then become predominantly depolarizing at high sound pressure. 3. The asymmetry of the inner and outer hair cell receptor potentials are manifested instantaneously except at high stimulus levels when the depolarizing responses of outer hair cells take several cycles to develop. 4. At the offset of intense tones outer hair cell membrane potentials remain depolarized by 1‐2 mV above their resting value and return to normal over a period depending on the level and duration of the tone. 5. In response to tones above about 2 kHz and at levels below about 90 dB the wave forms of outer hair cell receptor potentials are virtually symmetrical without measurable d.c. components. In response to tones close to their best frequencies (16‐21 kHz), inner hair cells in the basal turn generate large depolarizing (d.c.) receptor potentials while outer hair cells from this region of the cochlea do not generate significant voltage responses. 6. Frequency tuning curves were derived for inner and outer hair cells from the amplitude‐intensity relationships of their d.c. and phasic (a.c.) receptor potentials respectively. When the latter were compensated for the low‐pass characteristics of the recording system and the hair cell time constant, the frequency selectivity of inner and outer hair cells are similar. 7. The response properties of inner and outer hair cells in the basal turn of the guinea‐pig cochlea are discussed in relation to their proposed roles in mechano‐electric transduction.
内淋巴电位的变化和交叉橄榄耳蜗束刺激改变了耳蜗力学。
DOI：
10.1126/science.7414321
发表时间：
1980
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Mountain,DC
通讯作者：
Mountain,DC