Human melatonin regulation is not mediated by the three cone photopic visual system.
Human melatonin regulation is not mediated by the three cone photopic visual system.
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DOI：
10.1210/jcem.86.1.7277
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发表时间：
2001
期刊：
影响因子：
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通讯作者：
G. Brainard;J. Hanifin;M. Rollag;Jeffrey M. Greeson;B. Byrne;G. Glickman;E. Gerner;B. Sanford
中科院分区：
文献类型：
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作者：
G. Brainard;J. Hanifin;M. Rollag;Jeffrey M. Greeson;B. Byrne;G. Glickman;E. Gerner;B. Sanford
本研究的目的是通过确定不同波长对光诱导褪黑激素抑制的影响，来测试三锥光视系统是否是人类昼夜节律调节的主要眼部光感受器输入。睡眠模式稳定（起床时间7:30 AM +/- 12 min）、色觉正常的健康受试者在夜间暴露于505 nm或555nm的全视野单色刺激或黑暗中90 min。暴露前后收集的血浆被量化褪黑激素。暴露于10次505 nm辐照下的受试者在平均暴露前褪黑激素值之间没有显着差异（F=0.505）。拟合褪黑素抑制数据的s型影响-响应曲线（R(2)=0.97）表明，9.34 x 10（12）个光子/cm(2)/秒诱导半饱和响应（ED(50)），而6.84 x 10（13）个光子/cm(2)/秒诱导饱和褪黑素抑制响应。此外，在505 nm处，4.19 x 10（13）光子/厘米(2)/秒的剂量显著强于在555 nm处的相同光子剂量（P < 0.01）。这些数据表明，介导人类光视觉的视锥系统并不是主要的光感受器系统，通过光刺激来调节褪黑激素。
The aim of this study was to test if the three cone photopic visual system is the primary ocular photoreceptor input for human circadian regulation by determining the effects of different wavelengths on light-induced melatonin suppression. Healthy subjects with stable sleeping patterns (wake-up time 7:30 AM +/- 12 min) and normal color vision were exposed at night to full-field 505 nm or 555 nm monochromatic stimuli or darkness for 90 min. Plasma collected before and after exposures was quantified for melatonin. Subjects exposed to 10 irradiances at 505 nm showed no significant differences across mean pre-exposure melatonin values (F=0.505). A sigmoidal fluence-response curve fitted to the melatonin suppression data (R(2)=0.97) indicated that 9.34 x 10(12) photons/cm(2)/sec induced a half-saturation response (ED(50)) while 6.84 x 10(13) photons/cm(2)/sec induced a saturation melatonin suppression response. Further, a dose of 4.19 x 10(13) photon/cm(2)/sec at 505 nm was significantly stronger (P < 0.01) than an equal photon dose at 555 nm for melatonin suppression. These data demonstrate that the cone system that mediates human photopic vision is not the primary photoreceptor system to tranduce light stimuli for melatonin regulation.