The multifaceted oncogene SND1 in cancer: focus on hepatocellular carcinoma.
The multifaceted oncogene SND1 in cancer: focus on hepatocellular carcinoma.
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DOI：
10.20517/2394-5079.2018.34
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发表时间：
2018-01-01
期刊：
影响因子：
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通讯作者：
Sarkar, Devanand
中科院分区：
文献类型：
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作者：
Chidambaranathan-Reghupaty, Saranya;Mendoza, Rachel;Sarkar, Devanand
葡萄球菌核酸酶和tudor结构域包含1（SND1）是一种蛋白质，调节一系列复杂的功能。它通过转录激活、mRNA降解、mRNA稳定化、泛素化和可变剪接来控制基因表达。二十多年的研究积累了SND1作为致癌基因在各种癌症中的作用的证据。它是癌症标志如增殖、侵袭、迁移、血管生成和转移的促进剂。除了这些功能外，它还在脂质代谢，炎症和应激反应中发挥作用。SND1参与这些不同的功能使其与大多数癌基因不同，这些癌基因相对更专注于其作用。这在肝细胞癌（HCC）的情况下变得重要，因为除了典型的癌症驱动因素之外，脂质代谢失调和慢性炎症等因素也会使肝细胞易患HCC。本文综述了SND1的研究进展，特别是与肝癌相关的研究进展，并对其作为治疗靶点的前景进行了展望。
Staphylococcal nuclease and tudor domain containing 1 (SND1) is a protein that regulates a complex array of functions. It controls gene expression through transcriptional activation, mRNA degradation, mRNA stabilization, ubiquitination and alternative splicing. More than two decades of research has accumulated evidence of the role of SND1 as an oncogene in various cancers. It is a promoter of cancer hallmarks like proliferation, invasion, migration, angiogenesis and metastasis. In addition to these functions, it has a role in lipid metabolism, inflammation and stress response. The participation of SND1 in such varied functions makes it distinct from most oncogenes that are relatively more focused in their role. This becomes important in the case of hepatocellular carcinoma (HCC) since in addition to typical cancer drivers, factors like lipid metabolism deregulation and chronic inflammation can predispose hepatocytes to HCC. The objective of this review is to provide a summary of the current knowledge available on SND1, specifically in relation to HCC and to shed light on its prospect as a therapeutic target.