Molecular effects of uptake of gold nanoparticles in HeLa cells
Molecular effects of uptake of gold nanoparticles in HeLa cells
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DOI：
10.1002/cbic.200700165
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发表时间：
2007-07-23
期刊：
影响因子：
3.2
通讯作者：
Maiti, Souvik
中科院分区：
文献类型：
--
作者：
Khan, Jameel Ahmad;Pillai, Beena;Maiti, Souvik
醇金：纳米颗粒的毒理基因组学可以揭示细胞内环境的微妙但临床相关的变化，这些变化是由纳米颗粒在细胞内积累的下游效应引起的。利用DNA微阵列进行的全基因组表达谱分析显示，金纳米颗粒的内在化与HeLa细胞中转录的重大变化无关。
Mellow gold: Toxicogenomics of nanoparticles can expose subtle yet clinically relevant alterations in the intracellular environment that arise from downstream effects of nanoparticle accumulation inside cells. Genome-wide expression profiling by using DNA microarrays revealed that internalization of gold nanoparticles is not associated with gross changes in transcription in HeLa cells.