Notch directs telencephalic development and controls neocortical neuron fate determination by regulating microRNA levels.
Notch directs telencephalic development and controls neocortical neuron fate determination by regulating microRNA levels.
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Noch通过调节microRNA水平来指导端脑发育和控制新皮质神经元命运的决定。
DOI：
10.1242/dev.201408
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发表时间：
2023-06-01
期刊：
影响因子：
4.6
通讯作者：
Torre, Anna La
中科院分区：
文献类型：
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作者：
Han, Jisoo S;Fishman-Williams, Elizabeth;Decker, Steven C;Hino, Keiko;Reyes, Raenier V;Brown, Nadean L;Simo, Sergi;Torre, Anna La
中枢神经系统包含由多能神经祖细胞产生的无数不同类型的细胞。神经祖细胞根据其空间位置获得不同的细胞身份，但它们也会受到时间线索的影响，随着时间的推移产生不同的细胞群。例如，大脑新皮质的祖细胞按照众所周知的顺序产生不同的兴奋性投射神经元群。 Notch信号通路在此过程中发挥着至关重要的作用，但Notch影响祖细胞命运决定的分子机制尚未完全解决。在这里，我们表明Notch信号对于新皮质和海马形态发生以及胼胝体和脉络丛的发育至关重要。我们的数据还表明，在新皮质中，Notch 通过调节包括 let-7、miR-99a/100 和 miR-125b 在内的两个 microRNA 簇来控制投射神经元的命运决定。我们的研究结果总体表明，平衡的 Notch 信号传导对于端脑发育至关重要，Notch 和 miRNA 之间的相互作用对于控制新皮质祖细胞行为和神经元细胞命运决定至关重要。摘要：Notch 信号传导通过上调 microRNA let-7、miR-99a/100 和 miR-125b 来促进小鼠大脑中晚生皮质命运的神经发生。
The central nervous system contains a myriad of different cell types produced from multipotent neural progenitors. Neural progenitors acquire distinct cell identities depending on their spatial position, but they are also influenced by temporal cues to give rise to different cell populations over time. For instance, the progenitors of the cerebral neocortex generate different populations of excitatory projection neurons following a well-known sequence. The Notch signaling pathway plays crucial roles during this process, but the molecular mechanisms by which Notch impacts progenitor fate decisions have not been fully resolved. Here, we show that Notch signaling is essential for neocortical and hippocampal morphogenesis, and for the development of the corpus callosum and choroid plexus. Our data also indicate that, in the neocortex, Notch controls projection neuron fate determination through the regulation of two microRNA clusters that include let-7, miR-99a/100 and miR-125b. Our findings collectively suggest that balanced Notch signaling is crucial for telencephalic development and that the interplay between Notch and miRNAs is essential for the control of neocortical progenitor behaviors and neuron cell fate decisions. Summary: Notch signaling promotes the neurogenesis of late-born cortical fates in mouse brain by upregulating the microRNAs let-7, miR-99a/100 and miR-125b.
DOI：
10.1002/dvdy.24638
发表时间：
2018-08
期刊：
Developmental dynamics : an official publication of the American Association of Anatomists
影响因子：
--
作者：
Maurer KA;Kowalchuk A;Shoja-Taheri F;Brown NL
通讯作者：
Brown NL